Nutrition & Food Sciences
Permanent URI for this collectionhttps://hdl.handle.net/11274/9554
Browse
Browsing Nutrition & Food Sciences by Author "Beaudry, Rhys I."
Now showing 1 - 4 of 4
- Results Per Page
- Sort Options
Item Cardiac mechanisms for low aerobic power in anthracycline treated, older, long-term breast cancer survivors(BMC, 2022) Beaudry, Rhys I.; Haykowsky, Mark J.; MacNamara, James P.; Tucker, Wesley J.; Rao, Roshni; Haley, Barbara; Sarma, SatyamBreast cancer survivors have reduced peak aerobic capacity (VO2peak) which may be related to latent or lingering chemotherapy induced cardiac damage. Nine, older (67 ± 3 years), long-term survivors (9.8 years) of anthracycline based chemotherapy and age- and sex-matched healthy controls were recruited and tested to determine whether: i) VO2peak remains reduced in long-term survivorship; and ii) reductions in VO2peak are due to cardiac dysfunction. VO2peak was significantly reduced in breast cancer survivors relative to healthy controls (15.9 ± 2.0 vs 19.9 ± 3.1 ml/kg/min, p = 0.006), however the heart rate and stroke volume responses to exercise were normal (heart rate reserve; 88 ± 9 vs 85 ± 10 bpm, p = 0.62: stroke volume reserve; 13 ± 6 vs 13 ± 9 ml,p = 0.94). These findings indicate low-normal ventricular size in long-term breast cancer survivors, but normal reserve function.Item Impact of exercise training on peak oxygen uptake and its determinants in heart failure with preserved ejection fraction(Lippincott, 2016) Tucker, Wesley J.; Nelson, Michael D.; Beaudry, Rhys I.; Halle, Martin; Sarma, Satyam; Kitzman, Dalane W.; La Gerche, Andre; Haykowsky, Mark J.Heart failure with preserved ejection (HFpEF) accounts for over 50 % of all HF cases, and the proportion is higher among women and older individuals. A hallmark feature of HFpEF is dyspnoea on exertion and reduced peak aerobic power (VO2peak) secondary to central and peripheral abnormalities that result in reduced oxygen delivery to and/or utilisation by exercising skeletal muscle. The purpose of this brief review is to discuss the role of exercise training to improve VO2peak and the central and peripheral adaptations that reduce symptoms following physical conditioning in patients with HFpEF.Item Meta-analysis of exercise training on left ventricular ejection fraction in heart failure with reduced ejection fraction: A 10-year update(Elsevier, 2019) Tucker, Wesley J.; Beaudry, Rhys I.; Liang, Yuanyuan; Clark, Alexander M.; Tomczak, Corey R.; Nelson, Michael D.; Oyvind, Ellingsen; Haykowsky, Mark J.BACKGROUND: The role of exercise training modality to attenuate left ventricular (LV) remodeling in heart failure patients with reduced ejection fraction (HFrEF) remains uncertain. The authors performed a systematic review and meta-analysis of published reports on exercise training (moderate-intensity continuous aerobic, high-intensity interval aerobic, and resistance exercise) and LV remodeling in clinically stable HFrEF patients.Item Meta-analysis of exercise training on vascular endothelial function in cancer survivors(SAGE, 2018) Beaudry, Rhys I.; Liang, Yuanyuan; Boyton, Steven T.; Tucker, Wesley J.; Brothers, Matthew; Daniel, Kathryn M.; Rao, Roshni; Haykowsky, Mark J.Cancer and cardiovascular disease (CVD) are leading causes of morbidity and mortality in the United States. Vascular endothelial dysfunction, an important contributor in the development of CVD, improves with exercise training in patients with CVD. However, the role of regular exercise to improve vascular function in cancer survivors remains equivocal. We performed a meta-analysis to determine the effect of exercise training on vascular endothelial function in cancer survivors. We searched PubMed (1975 to 2016), EMBASE CINAHL (1937 to 2016), OVID MEDLINE (1948 to 2016), and Cochrane Central Registry of Controlled Trials (1991 to 2016) using search terms: vascular function, endothelial function, flow-mediated dilation [FMD], reactive hyperemia, exercise, and cancer. Studies selected were randomized controlled trials of exercise training on vascular endothelial function in cancer survivors. We calculated pooled effect sizes and performed a meta-analysis. We identified 4 randomized controlled trials (breast cancer, n=2; prostate cancer, n=2) measuring vascular endothelial function by FMD (n=3) or reactive hyperemia index (n=1), including 163 cancer survivors (exercise training, n=82; control, n=81). Aerobic exercise training improved vascular function (n=4 studies; standardized mean difference [95% CI]=0.65 [0.33, 0.96], I2=0%; FMD, weighted mean difference [WMD]=1.28 [0.22, 2.34], I2=23.2%) and peak exercise oxygen uptake (3 trials; WMD [95% CI]=2.22 [0.83, 3.61] mL/kg/min; I2=0%). Our findings indicate that exercise training improves vascular endothelial function and exercise capacity in breast and prostate cancer survivors.