Meta-analysis of exercise training on vascular endothelial function in cancer survivors

Date

2018

Authors

Beaudry, Rhys I.
Liang, Yuanyuan
Boyton, Steven T.
Tucker, Wesley J.
Brothers, Matthew
Daniel, Kathryn M.
Rao, Roshni
Haykowsky, Mark J.

Journal Title

Journal ISSN

Volume Title

Publisher

SAGE

Abstract

Cancer and cardiovascular disease (CVD) are leading causes of morbidity and mortality in the United States. Vascular endothelial dysfunction, an important contributor in the development of CVD, improves with exercise training in patients with CVD. However, the role of regular exercise to improve vascular function in cancer survivors remains equivocal. We performed a meta-analysis to determine the effect of exercise training on vascular endothelial function in cancer survivors. We searched PubMed (1975 to 2016), EMBASE CINAHL (1937 to 2016), OVID MEDLINE (1948 to 2016), and Cochrane Central Registry of Controlled Trials (1991 to 2016) using search terms: vascular function, endothelial function, flow-mediated dilation [FMD], reactive hyperemia, exercise, and cancer. Studies selected were randomized controlled trials of exercise training on vascular endothelial function in cancer survivors. We calculated pooled effect sizes and performed a meta-analysis. We identified 4 randomized controlled trials (breast cancer, n=2; prostate cancer, n=2) measuring vascular endothelial function by FMD (n=3) or reactive hyperemia index (n=1), including 163 cancer survivors (exercise training, n=82; control, n=81). Aerobic exercise training improved vascular function (n=4 studies; standardized mean difference [95% CI]=0.65 [0.33, 0.96], I2=0%; FMD, weighted mean difference [WMD]=1.28 [0.22, 2.34], I2=23.2%) and peak exercise oxygen uptake (3 trials; WMD [95% CI]=2.22 [0.83, 3.61] mL/kg/min; I2=0%). Our findings indicate that exercise training improves vascular endothelial function and exercise capacity in breast and prostate cancer survivors.

Description

Article originally published in Integrative Cancer Therapies, 17(2). English. Published online 2018. https://doi.org/10.1177/1534735418756193

Keywords

Exercise training, Vascular endothelial function,, Cancer, Meta-analysis

Citation

This is the published version of an article that is available at https://doi.org/10.1177/1534735418756193. Recommended citation: Beaudry, R. I., Liang, Y., Boyton, S. T., Tucker, W. J., Brothers, R. M., Daniel, K. M., Rao, R., & Haykowsky, M. J. (2018). Meta-analysis of exercise training on vascular endothelial function in cancer survivors. Integrative Cancer Therapies, 17(2), 192–199. This item has been deposited in accordance with publisher copyright and licensing terms and with the author’s permission.