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Browsing College of Health Sciences by Subject "Abobotulinumtoxin A"

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    Goal attainment after treatment with Abobotulinumtoxina and a tailored home therapy programme in children with upper limb spasticity: Descriptive, exploratory analysis of a large randomized, controlled study
    (Medical Journals Sweden, 2022) Carranza-del Rio, Jorge; Dursun, NIgar; Cekmece, Cigdem; Bonikowski, Marcin; Pyrzanowska, Weronika; Dabrowski, Edward; Tilton, Ann; Oleszek, Joyce; Volteau, Magali; Page, Simon; Shierk, Angela; Delgado, Mauricio R.
    Objective: This exploratory analysis of a large, randomized, double-blind study (NCT02106351) describes the effect of treatment with abobotulinumtoxinA followed by a tailored home exercises therapy programme in enabling children with upper limb spasticity due to cerebral palsy to achieve their functional goals using goal attainment scaling (GAS). Methods: Children with cerebral palsy and spasticity in ≥ 1 upper limb received up to 4 injection cycles of abobotulinumtoxinA (2 U/kg (cycle 1 only), 8U/kg and 16U/kg) into the elbow and wrist flexors and other upper limb muscles selected to support individual treatment goals. Children followed a home exercises therapy programme, which included stretches and exercises specifically chosen to facilitate goal achievement and engagement in activities. Results: For cycle 1, most children had active function goals set as their primary goal (69.7% vs 19.2% passive function goals). GAS T- scores and goal responder rates at week 16 indicated that most types of primary goal were achieved at least as expected during cycle 1 (all groups). Primary goal GAS T-scores were generally maintained for the first 3 abobotulinumtoxinA treatment cycles. Conclusion: Most children with upper limb spasticity treated with repeat cycles of abobotulinumtoxinA supported by an individualized home exercises therapy programme achieved their functional goals.