Goal attainment after treatment with Abobotulinumtoxina and a tailored home therapy programme in children with upper limb spasticity: Descriptive, exploratory analysis of a large randomized, controlled study

Date
2022
Authors
Carranza-del Rio, Jorge
Dursun, NIgar
Cekmece, Cigdem
Bonikowski, Marcin
Pyrzanowska, Weronika
Dabrowski, Edward
Tilton, Ann
Oleszek, Joyce
Volteau, Magali
Page, Simon
Journal Title
Journal ISSN
Volume Title
Publisher
Medical Journals Sweden
Abstract

Objective: This exploratory analysis of a large, randomized, double-blind study (NCT02106351) describes the effect of treatment with abobotulinumtoxinA followed by a tailored home exercises therapy programme in enabling children with upper limb spasticity due to cerebral palsy to achieve their functional goals using goal attainment scaling (GAS).


Methods: Children with cerebral palsy and spasticity in ≥ 1 upper limb received up to 4 injection cycles of abobotulinumtoxinA (2 U/kg (cycle 1 only), 8U/kg and 16U/kg) into the elbow and wrist flexors and other upper limb muscles selected to support individual treatment goals. Children followed a home exercises therapy programme, which included stretches and exercises specifically chosen to facilitate goal achievement and engagement in activities.


Results: For cycle 1, most children had active function goals set as their primary goal (69.7% vs 19.2% passive function goals). GAS T- scores and goal responder rates at week 16 indicated that most types of primary goal were achieved at least as expected during cycle 1 (all groups). Primary goal GAS T-scores were generally maintained for the first 3 abobotulinumtoxinA treatment cycles.


Conclusion: Most children with upper limb spasticity treated with repeat cycles of abobotulinumtoxinA supported by an individualized home exercises therapy programme achieved their functional goals.

Description
Article originally published in Journal of Rehabilitation Medicine, 54. English. Published online 2022. https://doi.org/10.2340/jrm.v54.2540
Keywords
Abobotulinumtoxin A, Cerebral palsy, Goal attainment scaling, Physical therapies, Upper limb.
Citation
This is the published version of an article that is available at https://doi.org/10.2340/jrm.v54.2540. Recommended citation: Carranza-del Río, J., Dursun, N., Cekmece, C., Bonikowski, M., Pyrzanowska, W., Dabrowski, E., Tilton, A., Oleszek, J., Volteau, M., Page, S., Shierk, A., & Delgado, M. R. (2022). Goal attainment after treatment with Abobotulinumtoxina and a tailored home therapy programme in children with upper limb spasticity: Descriptive, exploratory analysis of a large randomized, controlled study. Journal of Rehabilitation Medicine, 54. This item has been deposited in accordance with publisher copyright and licensing terms and with the author’s permission.