Goal attainment after treatment with Abobotulinumtoxina and a tailored home therapy programme in children with upper limb spasticity: Descriptive, exploratory analysis of a large randomized, controlled study

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dc.contributor.authorCarranza-del Rio, Jorge
dc.contributor.authorDursun, NIgar
dc.contributor.authorCekmece, Cigdem
dc.contributor.authorBonikowski, Marcin
dc.contributor.authorPyrzanowska, Weronika
dc.contributor.authorDabrowski, Edward
dc.contributor.authorTilton, Ann
dc.contributor.authorOleszek, Joyce
dc.contributor.authorVolteau, Magali
dc.contributor.authorPage, Simon
dc.contributor.authorShierk, Angela
dc.contributor.authorDelgado, Mauricio R.
dc.creator.orcidhttps://orcid.org/0000-0001-9813-6659
dc.date.accessioned2023-04-06T14:32:52Z
dc.date.available2023-04-06T14:32:52Z
dc.date.issued2022
dc.descriptionArticle originally published in Journal of Rehabilitation Medicine, 54. English. Published online 2022. https://doi.org/10.2340/jrm.v54.2540
dc.description.abstractObjective: This exploratory analysis of a large, randomized, double-blind study (NCT02106351) describes the effect of treatment with abobotulinumtoxinA followed by a tailored home exercises therapy programme in enabling children with upper limb spasticity due to cerebral palsy to achieve their functional goals using goal attainment scaling (GAS).en_US
dc.description.abstractMethods: Children with cerebral palsy and spasticity in ≥ 1 upper limb received up to 4 injection cycles of abobotulinumtoxinA (2 U/kg (cycle 1 only), 8U/kg and 16U/kg) into the elbow and wrist flexors and other upper limb muscles selected to support individual treatment goals. Children followed a home exercises therapy programme, which included stretches and exercises specifically chosen to facilitate goal achievement and engagement in activities.
dc.description.abstractResults: For cycle 1, most children had active function goals set as their primary goal (69.7% vs 19.2% passive function goals). GAS T- scores and goal responder rates at week 16 indicated that most types of primary goal were achieved at least as expected during cycle 1 (all groups). Primary goal GAS T-scores were generally maintained for the first 3 abobotulinumtoxinA treatment cycles.
dc.description.abstractConclusion: Most children with upper limb spasticity treated with repeat cycles of abobotulinumtoxinA supported by an individualized home exercises therapy programme achieved their functional goals.
dc.identifier.citationThis is the published version of an article that is available at https://doi.org/10.2340/jrm.v54.2540. Recommended citation: Carranza-del Río, J., Dursun, N., Cekmece, C., Bonikowski, M., Pyrzanowska, W., Dabrowski, E., Tilton, A., Oleszek, J., Volteau, M., Page, S., Shierk, A., & Delgado, M. R. (2022). Goal attainment after treatment with Abobotulinumtoxina and a tailored home therapy programme in children with upper limb spasticity: Descriptive, exploratory analysis of a large randomized, controlled study. Journal of Rehabilitation Medicine, 54. This item has been deposited in accordance with publisher copyright and licensing terms and with the author’s permission.en_US
dc.identifier.urihttps://hdl.handle.net/11274/14802
dc.identifier.urihttps://doi.org/10.2340/jrm.v54.2540
dc.language.isoen_USen_US
dc.publisherMedical Journals Swedenen_US
dc.rights.holderCopyright (c) 2022 Jorge Carranza-del Río , Nigar Dursun, Cigdem Cekmece, Marcin Bonikowski, Weronika Pyrzanowska, Edward Dabrowski , Ann Tilton, Joyce Oleszek, Magali Volteau, Simon Page, Angela Shierk, Mauricio Delgado
dc.rights.licenseCC BY-NC 4.0
dc.subjectAbobotulinumtoxin Aen_US
dc.subjectCerebral palsyen_US
dc.subjectGoal attainment scalingen_US
dc.subjectPhysical therapiesen_US
dc.subjectUpper limb.en_US
dc.titleGoal attainment after treatment with Abobotulinumtoxina and a tailored home therapy programme in children with upper limb spasticity: Descriptive, exploratory analysis of a large randomized, controlled studyen_US
dc.typeArticleen_US

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