The impact of whole pureed mango on inflammatory biomarkers and immune function after post-exhaustive exercise in healthy sedentary young adults

Objective: This study aimed to investigate the effects of whole pureed mango smoothies on inflammatory biomarkers, Interleukin 10 (IL-10), IL-1β, IL-6, IL-8, and TNF-α, and immune function, CD4+, and CD8+, after post-exhaustive exercise in healthy sedentary young adults. Methods: Thirty-four healthy men and women were recruited for this randomized, placebo-control, cross-over, 10-week study. Participants were randomized to consume 250g mango smoothie or 185g placebo smoothie daily. Each treatment arm lasted 4 weeks, with a 2-week washout period between treatments. Anthropometric measurements such as weight, height, and body composition via Dual-energy X-ray absorptiometry were collected. Overnight fasted venous blood was collected to evaluate inflammatory biomarkers and immune cells, IL-10, IL-1β, IL-6, IL-8, TNF-α, CD4+, and CD8+. All measurements were collected at the beginning and the end of each treatment arm. Differences within and between treatments were analyzed using repeated measures ANOVA test. Results: A total of 25 participants completed the mango treatment, and 25 participants completed the placebo treatment. At the end of the study, there was a significant difference between groups in cell concentration count-dead p < 0.001. There was also significant change within the mango group in IL-10 between baseline and at 0-minutes post-exercise (p=0.036), and baseline and 2-hr post-exercise (p=0.031). There was also a significant change in the placebo group from fasted blood draw at final visit and 0-minutes post-exercise (p=0.029) and fasted blood draw at final visit and 1-hr post-exercise (p=0.021). There was a significant change in CD8(+) T Lymphocytes (UR) in both groups between baseline and 2-hr post-exercise (p=0.022 and p=0.030, respectively). There was also a significant increase in pro-inflammatory biomarkers IL-1β, IL-6, IL-8, and TNF-α in the placebo group but not in the mango group. Although it was not significant, there was a trend in decreased inflammatory biomarkers in the mango treatment group.
Conclusions: The findings of this study suggest that consuming whole pureed mango may decrease inflammatory biomarkers after post-exhaustive exercise in sedentary young adults.