Effect of alcohol after muscle-damaging resistance exercise on muscular performance recovery and inflammatory capacity in women




Duplanty, Anthony A.
Levitt, Danielle E.
Luk, Hui-ying
McFarlin, Brian K.
Hill, David W.
Vingren, Jakob L.

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Purpose: To investigate the effect of acute alcohol consumption on muscular performance recovery, assessed by maximal torque production, and on inflammatory capacity, assessed by lipopolysaccharide (LPS)-stimulated cytokine production, following muscle-damaging resistance exercise in women.

Methods: Thirteen recreationally resistance-trained women completed two identical exercise bouts (300 maximal single-leg eccentric leg extensions) followed by alcohol (1.09 g ethanol kg−1 fat-free body mass) or placebo ingestion. Blood was collected before (PRE), and 5 (5 h-POST), 24 (24 h-POST), and 48 (48 h-POST) hours after exercise and analyzed for LPS-stimulated cytokine production (TNF-α, IL-1β, IL-6, and IL-8 and IL-10). Maximal torque production (concentric, eccentric, isometric) was measured for each leg at PRE, 24 h-POST, and 48 h-POST.

Results: Although the exercise bout increased LPS-stimulated production of TNF-α (%change from PRE: 5 h-POST 109%; 24 h-POST 49%; 48 h-POST 40%) and decreased LPS-stimulated production of IL-8 (5 h-POST −40%; 24 h-POST −50%; 48 h-POST: −43%) and IL-10 (5 h-POST: −37%; 24 h-POST −32%; 48 h-POST −31%), consuming alcohol after exercise did not affect this response. Regardless of drink condition, concentric, eccentric, and isometric torque produced by the exercised leg were lower at 24 h-POST (concentric 106 ± 6 Nm, eccentric 144 ± 9 Nm, isometric 128 ± 8 Nm; M ± SE) compared to PRE (concentric 127 ± 7 Nm, eccentric 175 ± 11 Nm, isometric 148 ± 8 Nm). Eccentric torque production was partially recovered and isometric torque production was fully recovered by 48 h-POST.

Conclusions: Alcohol consumed after muscle-damaging resistance exercise does not appear to affect inflammatory capacity or muscular performance recovery in resistance-trained women. Combined with previous findings in men, these results suggest a gender difference regarding effects of alcohol on exercise recovery.



Muscle damage, Resistance exercise, Binge drinking, Cytokines, Lipopolysaccharide


This is an abstract of an article that is available at https://doi.org/10.1007/s00421-017-3606-0. Recommended citation: Levitt, D. E., Luk, H.-Y., Duplanty, A. A., McFarlin, B. K., Hill, D. W., & Vingren, J. L. (2017). Effect of alcohol after muscle-damaging resistance exercise on muscular performance recovery and inflammatory capacity in women. European Journal of Applied Physiology, 117(6), 1195–1206. This item has been deposited in accordance with publisher copyright and licensing terms and with the author’s permission.