Bioactive plant metabolites in the management of non-communicable metabolic diseases: Looking at opportunities beyond the horizon

Date
2015
Authors
Prasad, Chandan
Imrhan, Victorine
Juma, Shanil
Maziarz, Mindy
Prasad, Anand
Tiernan, Casey
Vijayagopal, Parakat
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract

There has been an unprecedented worldwide rise in non-communicable metabolic diseases (NCDs), particularly cardiovascular diseases (CVD) and diabetes. While modern pharmacotherapy has decreased the mortality in the existing population, it has failed to stem the rise. Furthermore, a large segment of the world population cannot afford expensive pharmacotherapy. Therefore, there is an urgent need for inexpensive preventive measures to control the rise in CVD and diabetes and associated co-morbidities. The purpose of this review is to explore the role of food bioactives in prevention of NCDs. To this end, we have critically analyzed the possible utility of three classes of food bioactives: (a) resistant starch, a metabolically resistant carbohydrate known to favorably modulate insulin secretion and glucose metabolism; (b) cyclo (His-Pro), a food-derived cyclic dipeptides; and (c) polyphenol-rich berries. Finally, we have also briefly outlined the strategies needed to prepare these food-bioactives for human use.

Description
Article originally published in Metabolites, 5(4), 733–765. English. Published online 2015. https://doi.org/10.3390/metabo5040733
Keywords
Cardiovascular disease, Diabetes, Food bioactives, Functional food, Resistant starch, Polyphenols, Cyclo (His-Pro)
Citation
This is the published version of an article that is available at https://doi.org/10.3390/metabo5040733. Recommended citation: Prasad, C., Imrhan, V., Juma, S., Maziarz, M., Prasad, A., Tiernan, C., & Vijayagopal, P. (2015). Bioactive plant metabolites in the management of non-communicable metabolic diseases: Looking at opportunities beyond the horizon. Metabolites, 5(4), 733–765. This item has been deposited in accordance with publisher copyright and licensing terms and with the author’s permission.