Effect of mixed mushroom polyphenols in energy metabolism in human adipocytes

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dc.contributor.advisorShanil, Juma
dc.contributor.committeeMemberLeMieux, Monique
dc.contributor.committeeMemberTucker, Wesley
dc.creatorGonzalez Duarte, Lina
dc.creator.orcid0009-0009-2512-146X
dc.date.accessioned2023-10-06T20:13:38Z
dc.date.available2023-10-06T20:13:38Z
dc.date.created2023-08
dc.date.issuedAugust 2023
dc.date.submittedAugust 2023
dc.date.updated2023-10-06T20:13:39Z
dc.description.abstractObjective: This study aimed to evaluate the effects of dose-dependent mixed mushroom polyphenols on lipid accumulation and metabolic changes in human adipocytes. Methods: Cells were treated with dose-dependent mixed mushroom polyphenols with 50μg, 100μg, 200μg, and 400μg per ml of media, and evaluated for lipid accumulation, mitochondrial respiration, and glycolysis rate. Statistical analysis included means, medians, standard error, ANOVA test. Results: There was a positive dose-dependent effect for polyphenol concentration on adipocyte proliferation and ATP production from 50μg/ml up to 200μg/ml. In contrast, the maximal dose of polyphenol yielded a significant reduction in adipocyte proliferation and ATP production via mitochondrial respiration. Mushroom polyphenols did not affect ATP production via glycolysis under stress conditions. Conclusions: Preliminary results showed that as concentration of mushroom polyphenols increased, adipocytes proliferation significantly increased. Also, mushroom polyphenols at a higher concentration, reduced lipid accumulation, increased ATP production via mitochondrial respiration, and adipocytes were more energetic.
dc.format.mimetypeapplication/pdf
dc.identifier.uri
dc.identifier.urihttps://hdl.handle.net/11274/15500
dc.subjectHealth Sciences, Nutrition
dc.subject.otherPolyphenols
dc.subject.otherAdipocytes
dc.titleEffect of mixed mushroom polyphenols in energy metabolism in human adipocytes
dc.typeThesis
dc.type.materialtext
local.embargo.lift08/01/2024
local.embargo.terms08/01/2024
thesis.degree.collegeCollege of Health Sciences
thesis.degree.departmentNutrition and Food Sciences
thesis.degree.disciplineNutrition
thesis.degree.grantorTexas Woman's University
thesis.degree.nameMaster of Science
thesis.degree.programAPA 7th edition

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