Cognition and brain oxygen metabolism improves after bariatric surgery-induced weight loss: A pilot study

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dc.contributor.authorAnwar, Nareen
dc.contributor.authorTucker, Wesley J.
dc.contributor.authorPuzziferri, Nancy
dc.contributor.authorSamuel, T. Jake
dc.contributor.authorZaha, Vlad G.
dc.contributor.authorLingvay, Ildiko
dc.contributor.authorAlmandoz, Jaime
dc.contributor.authorWang, Jing
dc.contributor.authorGonzalez, Edward A.
dc.contributor.authorBrothers, Robert Matthew
dc.contributor.authorNelson, Michael D.
dc.contributor.authorThomas, Binu P.
dc.date.accessioned2023-04-27T18:30:33Z
dc.date.available2023-04-27T18:30:33Z
dc.date.issued2022
dc.descriptionArticle originally published in Frontiers in Endocrinology, 13, 1-9. English. Published Online 2022. https://doi.org/10.3389/fendo.2022.954127
dc.description.abstractObjective: The primary objectives of this pilot study were to assess cognition and cerebral metabolic rate of oxygen (CMRO2) consumption in people with severe obesity before (baseline), and again, 2- and 14-weeks after sleeve gastrectomy bariatric surgery.en_US
dc.description.abstractMethods: Six people with severe/class 3 obesity (52 ± 10 years, five females, body mass index (BMI) = 41.9 ± 3.9 kg/m2), and 10 normal weight sex- and age-matched healthy controls (HC) (48 ± 6 years, eight females, 22.8 ± 1.9 kg/m2). Global CMRO2 was measured non-invasively using MRI and cognition using the Integneuro testing battery.
dc.description.abstractResults: Following a sleeve gastrectomy induced weight loss of 6.4 ± 2.5 kg (% total-body-weight-lost = 5.4) over two-weeks, cognition total scores improved by 0.8 ± 0.5 T-scores (p=0.03, 15.8% improvement from baseline). Weight loss over 14-weeks post-surgery was 15.4 ± 3.6 kg (% total-body-weight-lost = 13.0%) and cognition improved by 1.1 ± 0.4 (p=0.003, 20.6% improvement from baseline). At 14-weeks, cognition was 6.4 ± 0.7, comparable to 6.0 ± 0.6 observed in the HC group. Baseline CMRO2 was significantly higher compared to the HC (230.4 ± 32.9 vs. 177.9 ± 33.9 µmol O2/100 g/min, p=0.02). Compared to baseline, CMRO2 was 234.3 ± 16.2 µmol O2/100 g/min at 2-weeks after surgery (p=0.8, 1.7% higher) and 217.3 ± 50.4 at 14-weeks (p=0.5, 5.7% lower) after surgery. 14-weeks following surgery, CMRO2 was similar to HC (p=0.17).
dc.description.abstractConclusion: Sleeve gastrectomy induced weight loss was associated with an increase in cognition and a decrease in CMRO2 observed 14-weeks after surgery. The association between weight loss, improved cognition and CMRO2 decrease should be evaluated in larger future studies.
dc.identifier.citationThis is the published version of an article that is available at https://doi.org/10.3389/fendo.2022.954127. Recommended citation: Anwar, N., Tucker, W. J., Puzziferri, N., Samuel, T. J., Zaha, V. G., Lingvay, I., Almandoz, J., Wang, J., Gonzales, E. A., Brothers, R. M., Nelson, M. D., & Thomas, B. P. (2022). Cognition and brain oxygen metabolism improves after bariatric surgery-induced weight loss: A pilot study. Frontiers in Endocrinology, 13, 1-9. This item has been deposited in accordance with publisher copyright and licensing terms and with the author’s permission.en_US
dc.identifier.urihttps://hdl.handle.net/11274/14903
dc.identifier.urihttps://doi.org/10.3389/fendo.2022.954127
dc.language.isoen_USen_US
dc.publisherFrontiers Mediaen_US
dc.rights.holder© 2022 Anwar, Tucker, Puzziferri, Samuel, Zaha, Lingvay, Almandoz, Wang, Gonzales, Brothers, Nelson and Thomas.
dc.rights.licenseCC BY 4.0
dc.subjectObesityen_US
dc.subjectCognitionen_US
dc.subjectCerebral metabolic rate of oxygenen_US
dc.subjectBariatric surgeryen_US
dc.subjectSleeve gastrectomyen_US
dc.subjectCerebral blood flowen_US
dc.subjectOxygen extraction fractionen_US
dc.subjectVenous oxygenationen_US
dc.titleCognition and brain oxygen metabolism improves after bariatric surgery-induced weight loss: A pilot studyen_US
dc.typeArticleen_US

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