An estimate of the incidence of bladder cancer in Africa: a systematic review and Bayesian meta-analysis

Date
2019-01
Authors
Adeloye, Davies
Harhay, Michael O.
Ayepola, Olayemi O.
Dos Santos, Jhonathan P. R.
David, Rotimi A.
Ogunlana, Olubanke O.
Gadanya, Muktar
Osamor, Victor C.
Amuta, Ann O.
Iweala, Emeka E.
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
Abstract

Objectives: To quantify the epidemiology of bladder cancer in Africa to guide a targeted public health response and support research initiatives.


Methods: We systematically searched publicly available sources for population‐based registry studies reporting the incidence of bladder cancer in Africa between January 1980 and June 2017. Crude incidence rates of bladder cancer were extracted. A Bayesian network meta‐analysis model was used to estimate incidence rates.


Results: The search returned 1328 studies. A total of 22 studies carried out across 15 African countries met our pre‐defined selection criteria. Heterogeneity across studies was high (I2 = 98.9%, P < 0.001). The pooled incidence of bladder cancer in Africa was 7.0 (95% credible interval 5.8–8.3) per 100 000 population in men and 1.8 (95% credible interval 1.2–2.6) per 100 000 in women. The incidence of bladder cancer was consistently higher in North Africa in both sexes. Among men, we estimated a pooled incidence of 10.1 (95% credible interval 7.9–11.9) per 100 000 in North Africa and 5.0 (95% credible interval 3.8–6.6) per 100 000 in sub‐Saharan Africa. In women, the pooled incidence was 2.0 (95% credible interval 1.0–3.0) per 100 000 and 1.5 (95% credible interval 0.9–2.0) per 100 000 in North Africa and sub‐Saharan Africa, respectively. Incidence rates increased significantly among men from 5.6 (95% credible interval 4.2–7.2) in the 1990s to 8.5 (95% credible interval 6.9–10.1) per 100 000 in 2010.


Conclusions: The present study suggests a growing incidence of bladder cancer in Africa in recent years, particularly among men and in North Africa. This study also highlights the lack of quality data sources and collection of essential clinical and epidemiological data in several African countries, and this hinders public health planning.

Description
Article originally published in International Journal of Urology, 26 (1), 102-112. English. Published online October 2018. https://doi.org/10.1111/iju.13824
Keywords
Africa, Bladder cancer, Schistosoma haematobium, Squamous cell carcinoma, Transitional cell carcinoma
Citation
This is the post-print version of an article that is available at https://doi.org/10.1111/iju.13824. Recommended citation: Adeloye, D., Harhay, M. O., Ayepola, O. O., Dos Santos, J. P. R., David, R. A., Ogunlana, O. O., Gadanya, M., Osamor, V. C., Amuta, A. O., Iweala, E. E., Auta, A., & Rebbeck, T. R. (2018). Estimate of the incidence of bladder cancer in Africa: A systematic review and Bayesian meta-analysis. International Journal of Urology, 26(1), 102–112. This item has been deposited in accordance with publisher copyright and licensing terms and with the author’s permission.
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