Acute supplementation with cannabidiol does not attenuate inflammation or improve measures of performance following strenuous exercise

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dc.contributor.authorCrossland, Brett
dc.contributor.authorRigby, B. Rhett
dc.contributor.authorDuplanty, Anthony A.
dc.contributor.authorKing, George A.
dc.contributor.authorJuma, Shanil
dc.contributor.authorLevine, Nicholas
dc.contributor.authorClark, Cayla E.
dc.contributor.authorRamirez, Kyndall P.
dc.contributor.authorVarone, Nicole L.
dc.date.accessioned2022-10-13T16:30:14Z
dc.date.available2022-10-13T16:30:14Z
dc.date.issued2022
dc.descriptionArticle originally published in Healthcare, 10(6), 1133. English. Published online 2022. https://doi.org/10.3390/healthcare10061133
dc.description.abstractSupplementation with cannabidiol (CBD) may expedite recovery when consumed after exercise. The purpose of this study was to determine if supplementation with CBD reduces inflammation and enhances performance following strenuous eccentric exercise in collegiate athletes. Twenty-four well-trained females (age = 21.2 ± 1.8 years, height = 166.4 ± 8 cm, weight = 64.9 ± 9.1 kg) completed 100 repetitions of unilateral eccentric leg extension to induce muscle damage. In this crossover design, participants were randomized to receive 5 mg/kg of CBD in pill form or a placebo 2 h prior to, immediately following, and 10 h following muscle damage. Blood was collected, and performance and fatigue were measured prior to, and 4 h, 24 h, and 48 h following the muscle damage. Approximately 28 days separated treatment administration to control for the menstrual cycle. No significant differences were observed between the treatments for inflammation, muscle damage, or subjective fatigue. Peak torque at 60°/s (p = 0.001) and peak isometric torque (p = 0.02) were significantly lower 24 h following muscle damage, but no difference in performance was observed between treatments at any timepoint. Cannabidiol supplementation was unable to reduce fatigue, limit inflammation, or restore performance in well-trained female athletes.en_US
dc.identifier.citationThis is the publisher’s version of an article that is available at https://doi.org/10.3390/healthcare10061133. Recommended citation: Crossland, B. W., Rigby, B. R., Duplanty, A. A., King, G. A., Juma, S., Levine, N. A., Clark, C. E., Ramirez, K. P., & Varone, N. L. (2022). Acute supplementation with cannabidiol does not attenuate inflammation or improve measures of performance following strenuous exercise. Healthcare, 10(6), 1133. This item has been deposited in accordance with publisher copyright and licensing terms and with the author’s permission.en_US
dc.identifier.urihttps://hdl.handle.net/11274/14061
dc.identifier.urihttps://doi.org/10.3390/healthcare10061133
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.rights.licenseCC BY 4.0
dc.subjectAnti-inflammatoryen_US
dc.subjectAthletesen_US
dc.subjectCytokinesen_US
dc.subjectEccentric exerciseen_US
dc.subjectFatigueen_US
dc.subjectHempen_US
dc.subjectMuscle damageen_US
dc.titleAcute supplementation with cannabidiol does not attenuate inflammation or improve measures of performance following strenuous exerciseen_US
dc.typeArticleen_US

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