Evaluation of cortical plasticity in children with cerebral palsy undergoing constraint-induced movement therapy based on functional near-infrared spectroscopy

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dc.contributor.authorCao, Jianwei
dc.contributor.authorKhan, Bilal
dc.contributor.authorHervey, Nathan
dc.contributor.authorTian, Fenghua
dc.contributor.authorDelgado, Mauricio R.
dc.contributor.authorClegg, Nancy J.
dc.contributor.authorSmith, Linsley
dc.contributor.authorRoberts, Heather
dc.contributor.authorTulchin-Francis, Kirsten
dc.contributor.authorShierk, Angela
dc.contributor.authorShagman, Laura
dc.contributor.authorMacFarlane, Duncan
dc.contributor.authorLiu, Hanli
dc.contributor.authorAlexandrakis, George
dc.creator.orcidhttps://orcid.org/0000-0003-2670-4981
dc.date.accessioned2023-03-17T16:19:54Z
dc.date.available2023-03-17T16:19:54Z
dc.date.issued2015
dc.descriptionArticle originally published in Journal of Biomedical Optics, 20(4), 046009. Published online 2015. https://doi.org/10.1117/1.jbo.20.4.046009
dc.description.abstractSensorimotor cortex plasticity induced by constraint-induced movement therapy (CIMT) in six children (10.2 2.1 years old) with hemiplegic cerebral palsy was assessed by functional near-infrared spectroscopy (fNIRS). The activation laterality index and time-to-peak/duration during a finger-tapping task and the resting-state functional connectivity were quantified before, immediately after, and 6 months after CIMT. These fNIRS-based metrics were used to help explain changes in clinical scores of manual performance obtained concurrently with imaging time points. Five age-matched healthy children (9.8 1.3 years old) were also imaged to provide comparative activation metrics for normal controls. Interestingly, the activation time-to-peak/duration for all sensorimotor centers displayed significant normalization immediately after CIMT that persisted 6 months later. In contrast to this improved localized activation response, the laterality index and resting-state connectivity metrics that depended on communication between sensorimotor centers improved immediately after CIMT, but relapsed 6 months later. In addition, for the subjects measured in this work, there was either a trade-off between improving unimanual versus bimanual performance when sensorimotor activation patterns normalized after CIMT, or an improvement occurred in both unimanual and bimanual performance but at the cost of very abnormal plastic changes in sensorimotor activity.en_US
dc.identifier.citationThis is a published version of an article that is available at https://doi.org/10.1117/1.jbo.20.4.046009. Recommended citation: Cao, J., Khan, B., Hervey, N., Tian, F., Delgado, M. R., Clegg, N. J., Smith, L., Roberts, H., Tulchin-Francis, K., Shierk, A., Shagman, L., MacFarlane, D., Liu, H., & Alexandrakis, G. (2015). Evaluation of cortical plasticity in children with cerebral palsy undergoing constraint-induced movement therapy based on functional near-infrared spectroscopy. Journal of Biomedical Optics, 20(4), 046009. This item has been deposited in accordance with publisher copyright and licensing terms and with the author’s permission.en_US
dc.identifier.urihttps://hdl.handle.net/11274/14684
dc.identifier.urihttps://doi.org/10.1117/1.jbo.20.4.046009
dc.language.isoen_USen_US
dc.publisherSociety of Photo-optical Instrumentation Engineers (SPIE)en_US
dc.rights.holder© The Authors
dc.rights.licenseCC BY 4.0
dc.subjectFunctional near-infrared spectroscopyen_US
dc.subjectCerebral palsyen_US
dc.subjectConstraint-induced movement therapyen_US
dc.subjectSensorimotor cortexen_US
dc.subjectResting-state functional connectivityen_US
dc.titleEvaluation of cortical plasticity in children with cerebral palsy undergoing constraint-induced movement therapy based on functional near-infrared spectroscopyen_US
dc.typeArticleen_US

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