Evaluation of cortical plasticity in children with cerebral palsy undergoing constraint-induced movement therapy based on functional near-infrared spectroscopy

Date
2015
Authors
Cao, Jianwei
Khan, Bilal
Hervey, Nathan
Tian, Fenghua
Delgado, Mauricio R.
Clegg, Nancy J.
Smith, Linsley
Roberts, Heather
Tulchin-Francis, Kirsten
Shierk, Angela
Journal Title
Journal ISSN
Volume Title
Publisher
Society of Photo-optical Instrumentation Engineers (SPIE)
Abstract

Sensorimotor cortex plasticity induced by constraint-induced movement therapy (CIMT) in six children (10.2 2.1 years old) with hemiplegic cerebral palsy was assessed by functional near-infrared spectroscopy (fNIRS). The activation laterality index and time-to-peak/duration during a finger-tapping task and the resting-state functional connectivity were quantified before, immediately after, and 6 months after CIMT. These fNIRS-based metrics were used to help explain changes in clinical scores of manual performance obtained concurrently with imaging time points. Five age-matched healthy children (9.8 1.3 years old) were also imaged to provide comparative activation metrics for normal controls. Interestingly, the activation time-to-peak/duration for all sensorimotor centers displayed significant normalization immediately after CIMT that persisted 6 months later. In contrast to this improved localized activation response, the laterality index and resting-state connectivity metrics that depended on communication between sensorimotor centers improved immediately after CIMT, but relapsed 6 months later. In addition, for the subjects measured in this work, there was either a trade-off between improving unimanual versus bimanual performance when sensorimotor activation patterns normalized after CIMT, or an improvement occurred in both unimanual and bimanual performance but at the cost of very abnormal plastic changes in sensorimotor activity.

Description
Article originally published in Journal of Biomedical Optics, 20(4), 046009. Published online 2015. https://doi.org/10.1117/1.jbo.20.4.046009
Keywords
Functional near-infrared spectroscopy, Cerebral palsy, Constraint-induced movement therapy, Sensorimotor cortex, Resting-state functional connectivity
Citation
This is a published version of an article that is available at https://doi.org/10.1117/1.jbo.20.4.046009. Recommended citation: Cao, J., Khan, B., Hervey, N., Tian, F., Delgado, M. R., Clegg, N. J., Smith, L., Roberts, H., Tulchin-Francis, K., Shierk, A., Shagman, L., MacFarlane, D., Liu, H., & Alexandrakis, G. (2015). Evaluation of cortical plasticity in children with cerebral palsy undergoing constraint-induced movement therapy based on functional near-infrared spectroscopy. Journal of Biomedical Optics, 20(4), 046009. This item has been deposited in accordance with publisher copyright and licensing terms and with the author’s permission.