5-HT2A/2C Receptors and lordosis behavior in the female rat
| dc.contributor.author | Wolf, Amy | |
| dc.contributor.committeeChair | Uphouse, Lynda | |
| dc.contributor.committeeMember | Droge, Michael | |
| dc.contributor.committeeMember | Hardcastle, James | |
| dc.contributor.committeeMember | Kowalski, Jacek | |
| dc.contributor.committeeMember | Mills, Nathniel | |
| dc.date.accessioned | 2022-10-16T19:49:57Z | |
| dc.date.available | 2022-10-16T19:49:57Z | |
| dc.date.issued | 1998-05 | |
| dc.description.abstract | The effects of hypothalamic infusion of serotonin (5-HT)2A/2C receptor compounds on lordosis behavior were examined in ovariectomized, hormone-primed (0.5 $\mu$g estradiol benzoate, subcutaneuosly (s.c.), followed 48 hr later with 500 $\mu$g progesterone, s.c.) rats. This hormone-priming condition resulted in some rats that were sexually receptive and some that showed low or no sexual behavior. Sexually receptive rats were inhibited when the 5-HT$\rm\sb{2A/2C}$ receptor antagonist, 3-(2-) 4-(4-fluorobenzoyl)-1-piperdinlyl(ethyl) -2,4(1H,3H)-quinazo-linedione tartrate, ketanserin, was infused into the ventromedial nucleus of the hypothalamus (VMN). Hormone-primed ovariectomized rats were more affected by the drug than were proestrous rats. The reason for this apparent difference in sensitivity to the drug is unknown. When ovariectomized, hormone-primed rats with low sexual receptivity received VMN infusion with the 5-HT$\rm\sb{2A/2C}$ receptor agonist, ($\pm$)-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl, DOI, sexual behavior increased. Similar increases in lordosis behavior were observed following infusion with the mixed 5-HT receptor compounds, 2-(1-piperazinyl) quinoline dimaleate, quipazine, and N-(3-trifluoromethyl-phenyl) piperazine hydrochloride, TFMPP. Facilitation of the behavior occurred within 15-20 min of agonist infusion, while inhibition following antagonist infusion occurred more rapidly. These findings are consistent with the hypothesis that 5-HT$\rm\sb{2A/2C}$ receptors in the VMN contribute to the facilitation of female rat sexual behavior. | |
| dc.identifier.uri | https://hdl.handle.net/11274/14093 | |
| dc.language.iso | en_US | en_US |
| dc.subject | Neurology | |
| dc.subject | Biological sciences | |
| dc.subject | Hypothalamus | |
| dc.subject | Serotonin | |
| dc.subject | Ventromedial nucleus | |
| dc.title | 5-HT2A/2C Receptors and lordosis behavior in the female rat | en_US |
| dc.type | Dissertation | en_US |
| thesis.degree.college | College of Arts and Sciences | en_US |
| thesis.degree.discipline | Molecular Biology | en_US |
| thesis.degree.grantor | Texas Woman's University | en_US |
| thesis.degree.level | Doctoral | en_US |
| thesis.degree.name | Doctor of Philosophy | en_US |