Expression levels of ALDH1A2 and ALDH1A3 are altered in human tissue biopsies in invasive squamous cell carcinoma

Simple item page
dc.contributor.advisorEverts, Helen B
dc.creatorNewman, Regina
dc.date.accessioned2022-01-06T22:18:10Z
dc.date.available2022-01-06T22:18:10Z
dc.date.created2021-12
dc.date.issued9/1/2021
dc.date.submittedDec-21
dc.date.updated2022-01-06T22:18:11Z
dc.description.abstractThe regulation of gene expression by retinoids has been shown to be profoundly altered in various types of precancerous and cancerous lesions, including cutaneous squamous cell carcinoma (cSCC). Aldehyde dehydrogenase family 1, subfamily members A2 (ALDH1A2) and A3 (ALDH1A3) participate in the oxidation of retinal to retinoic acid and their expression has been implicated in various types of cancers. The purpose of this study is to compare the intensity and localization of ALDH1A2 and ALDH1A3 in various stages of cSCC. Forty-two diseased biopsies and 32 healthy controls were used in this study. Immunohistochemistry was used to detect the immunoreactivity and localization of ALDH1A2 and ALDH1A3. Results showed percent ALDH1A2 positive cells were significantly higher in the tumor and stroma of actinic keratosis and invasive SCC groups than other groups. ALDH1A3 expression levels were significantly higher in tumors of all stages of cSCC compared to the epidermis of the control group.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/11274/13457
dc.language.isoen
dc.subjectCutaneous squamous cell carcinoma
dc.subjectALDH1A2
dc.subjectALDH1A3
dc.subjectRetinoic acid
dc.titleExpression levels of ALDH1A2 and ALDH1A3 are altered in human tissue biopsies in invasive squamous cell carcinoma
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentNutrition and Food Sciences
thesis.degree.disciplineNutrition
thesis.degree.grantorTexas Woman's University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
NEWMAN-THESIS-2021.pdf
Size:
863.83 KB
Format:
Adobe Portable Document Format
Download

License bundle

Now showing 1 - 2 of 2
No Thumbnail Available
Name:
LICENSE.txt
Size:
1.85 KB
Format:
Plain Text
Description:
Download
No Thumbnail Available
Name:
PROQUEST_LICENSE.txt
Size:
5.84 KB
Format:
Plain Text
Description:
Download

Collections

Nutrition & Food Sciences
2021 Theses and Dissertations