Diet and indices of bone breakdown and acid production in bed rest subjects

Simple item page
dc.contributor.authorWatts, Sarah Miriam
dc.contributor.committeeChairJuma, Shanil
dc.contributor.committeeMemberVijayagopal, Parakat
dc.date.accessioned2018-10-15T13:53:23Z
dc.date.available2018-10-15T13:53:23Z
dc.date.issued2012-05
dc.description.abstractDiet and acid-base balance can affect bone loss during simulated weightlessness. The present study evaluates the effects of acid and base components of diet on bone resorption markers before, during, and after 60-90 days of bed rest at -6° head-down tilt position. A total of eleven subjects (8M, 3F; age 26-44 y) participated in the present study. Urine samples from the subjects were analyzed for a relationship between dietary patterns and markers of bone metabolism. This study examines two procedures for estimating acid production in the body by comparing urinary net acid excretion (NAEindirect ) and by measuring the animal protein to potassium ratio, as estimated from dietary intake. It is hypothesized that both estimations would have significant correlations between markers of bone breakdown NTX (N-telopeptide) and PYD (pyridinoline). Results confirmed that bone resorption increased during bed rest as indicated by the collagen crosslinks NTX and PYD. In addition, significant correlations were recorded between NAEindirect and NTX (p<0.01), and PYD (p<0.01) during bed rest. However, the ratio of animal protein to potassium intake was not significantly correlated with NTX or PYD, suggesting further research on this method of approximating acid load is necessary.en_US
dc.identifier.urihttps://twu-ir.tdl.org/handle/11274/10477
dc.language.isoen_USen_US
dc.subjectHealth and environmental sciencesen_US
dc.subjectAgingen_US
dc.subjectBone lossen_US
dc.subjectWeightlessnessen_US
dc.subjectBed resten_US
dc.subjectBoneen_US
dc.subjectBone resorptionen_US
dc.subjectBone markersen_US
dc.subjectCollagen crosslinksen_US
dc.subjectNTX (N-telopeptide)en_US
dc.subjectPYD (pyridinoline)en_US
dc.subjectAcid-base homeostasisen_US
dc.subjectDietary aciden_US
dc.subjectDietary baseen_US
dc.subjectUrinary net acid excretion (NAE)en_US
dc.subjectAnimal to potassium ratioen_US
dc.titleDiet and indices of bone breakdown and acid production in bed rest subjectsen_US
dc.typeThesisen_US
thesis.degree.collegeCollege of Health Sciences
thesis.degree.departmentNutrition and Food Sciencesen_US
thesis.degree.disciplineNutrition
thesis.degree.grantorTexas Woman's University
thesis.degree.levelMasteren_US
thesis.degree.nameMaster of Scienceen_US

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
2012WattsOCR.pdf
Size:
12.72 MB
Format:
Adobe Portable Document Format
Description:
Download

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.68 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Nutrition & Food Sciences