Exercise Increases Insulin Content and Basal Secretion in Pancreatic Islets in Type 1 Diabetic Mice

Simple item page
dc.contributor.authorHuang, Han-Hung
dc.contributor.authorFarmer, Kevin
dc.contributor.authorWindscheffel, Jill
dc.contributor.authorYost, Katie
dc.contributor.authorPower, Mary
dc.contributor.authorWright, Douglas E.
dc.contributor.authorStehno-Bittel, Lisa
dc.date.accessioned2024-02-22T15:24:50Z
dc.date.available2024-02-22T15:24:50Z
dc.date.issued2011-09-11
dc.description.abstractExercise appears to improve glycemic control for people with type 1 diabetes (T1D). However, the mechanism responsible for this improvement is unknown. We hypothesized that exercise has a direct effect on the insulin-producing islets. Eight-week-old mice were divided into four groups: sedentary diabetic, exercised diabetic, sedentary control, and exercised control. The exercised groups participated in voluntary wheel running for 6 weeks. When compared to the control groups, the islet density, islet diameter, and β-cell proportion per islet were significantly lower in both sedentary and exercised diabetic groups and these alterations were not improved with exercise. The total insulin content and insulin secretion were significantly lower in sedentary diabetics compared to controls. Exercise significantly improved insulin content and insulin secretion in islets in basal conditions. Thus, some improvements in exercise-induced glycemic control in T1D mice may be due to enhancement of insulin content and secretion in islets.
dc.identifier.citationHuang, H.-H., Farmer, K., Windscheffel, J., Yost, K., Power, M., Wright, D. E., & Stehno-Bittel, L. (2011). Exercise increases insulin content and basal secretion in pancreatic islets in type 1 diabetic mice. Experimental Diabetes Research, 2011, 1–10. https://doi.org/10.1155/2011/481427
dc.identifier.urihttps://doi.org/10.1155/2011/481427
dc.identifier.urihttps://hdl.handle.net/11274/15774
dc.language.isoen_US
dc.rights.licenseCC BY
dc.titleExercise Increases Insulin Content and Basal Secretion in Pancreatic Islets in Type 1 Diabetic Mice
dc.typeArticle

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Exercise increases insulin content and basal secretion in pancreatic islets.pdf
Size:
4.17 MB
Format:
Adobe Portable Document Format
Download

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.67 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

School of Physical Therapy