Effect of cmvIL-10 on Ubiquitin mediated C-X-C receptor 4 signaling
| dc.contributor.author | Tajuddin, Kiran Hina | |
| dc.contributor.author | Spencer, Juliet | |
| dc.date.accessioned | 2021-01-20T17:45:37Z | |
| dc.date.available | 2021-01-20T17:45:37Z | |
| dc.date.issued | 2020 | |
| dc.description | Creative Arts and Research Symposium | en_US |
| dc.description.abstract | Human cytomegalovirus (HCMV) manipulates the immune system of its host by encoding viral proteins that imitate host cytokine and chemokine pathways. The HCMV gene UL111A encodes a homolog of human interleukin-10 (hIL-10), known as cmvIL-10. cmvIL-10 has many functions, including upregulating signaling from human CXC- chemokine receptor-4 (CXCR4) signaling in response to its known ligand CXCL12. cmvIL-10 promotes increased intracellular calcium flux and cell migration in response to CXCL12/CXCR4 that could assist in viral dissemination. Recent studies have shown that extracellular ubiquitin (UB) is also a natural ligand for CXCR4. This study will focus on whether cmvIL-10 also impacts UB mediated CXCR4 signaling and will examine the effects of cmvIl-10 on UB induced cell proliferation, migration, and cell signaling pathways. This research will lead to identify the possible role of cmvIL-10 in manipulating host cell signaling pathways during virus infection. | en_US |
| dc.identifier.uri | https://hdl.handle.net/11274/12620 | |
| dc.language.iso | en_US | en_US |
| dc.title | Effect of cmvIL-10 on Ubiquitin mediated C-X-C receptor 4 signaling | en_US |
| dc.type | Poster | en_US |