Testing Blast & Blunt Trauma Forces on Complex Neural Networks In Cerebral Organoids

Simple item page
dc.contributor.authorSilvosa, Marc Joshua
dc.contributor.authorLybrand, Zane R.
dc.date.accessioned2021-03-19T23:59:16Z
dc.date.available2021-03-19T23:59:16Z
dc.date.issued2021
dc.descriptionCreative Arts and Research Symposium
dc.descriptionCreative Arts and Research Symposiumen_US
dc.description.abstractUnderstanding the brain’s response to mild traumatic brain injuries (mTBIs) remains elusive. Repetitive mTBIs, for example, concussions, have been linked to neurodegeneration, microvascular changes, and neuroinflammation which suggests that they play a larger role in the development of neurological diseases such as Alzheimer’s disease and Chronic Traumatic Encephalopathy (CTE). In this study we are using human cerebral organoids to model repetitive mild brain injury. As a proof of concept experiment, we used a tabletop blast chamber to expose cerebral organoids to pressure forces experienced during mTBIs and characterized the response of brain tissue following exposure. Using extracellular electrophysiology, our current data set suggests that in response to blasts exposure, there is a decrease in organoid neuronal activity. We are planning to further characterize cortical brain properties of the organoids as well as neurodegeneration and neuroinflammation. These results will help to establish an in vitro model of mTBIs using cerebral organoids.
dc.description.departmentBiology
dc.description.sponsorshipSupported by Michigan State University and the United States Air Force
dc.identifier.urihttps://hdl.handle.net/11274/12912
dc.language.isoen_USen_US
dc.titleTesting Blast & Blunt Trauma Forces on Complex Neural Networks In Cerebral Organoidsen_US
dc.typePosteren_US

Files

Original bundle

Now showing 1 - 2 of 2
No Thumbnail Available
Name:
0200_Silvosa.mp4.vtt
Size:
7.69 KB
Format:
Unknown data format
Description:
English Subtitles
Download
No Thumbnail Available
Name:
0200_Silvosa.mp4
Size:
176.83 MB
Format:
Description:
Presentation Video
Download

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.68 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Student Creative Arts and Research Symposium | 2021