Chondroprotective action of tart cherry in the monosodium iodoacetate (MIA) rat model of osteoarthritis

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dc.contributor.advisorJuma, Shanil
dc.contributor.committeeMemberLeMieux, Monique
dc.contributor.committeeMemberPahlavani, Mandana
dc.creatorCrabtree, Keith E 1963-
dc.date.accessioned2023-11-03T20:10:33Z
dc.date.available2023-11-03T20:10:33Z
dc.date.created2023-08
dc.date.issuedAugust 2023
dc.date.submittedAugust 2023
dc.date.updated2023-11-03T20:10:33Z
dc.description.abstractObjective: To investigate the dose-dependent effects of whole tart cherry in a monosodium iodoacetate (MIA) induced rat model of osteoarthritis (OA). Methods: A total of forty, 45-day-old female CD rats were used for study. Thirty rats were injected with MIA to induce joint destruction and randomized into three groups of 10 animals each. Rats were fed a casein-based diet with two groups receiving whole tart cherry powder at 5% and 10% respectively for 48 days. Fasted blood samples and tissues of interest were analyzed. Results: Histological analysis of knee joint determined significant worsening of damage between control and MIA groups. There was a slight increase in TIMP-1 concentration. The introduction of tart cherry resulted in IL-10 levels which emulated non-MIA group level. Conclusions: Introduction of tart cherry powder achieved some reductions in pro-, and anti-inflammatory markers, but statistical significance between untreated MIA induced rats and those given tart cherry powder was with observed in aggrecan only.
dc.format.mimetypeapplication/pdf
dc.identifier.uri
dc.identifier.urihttps://hdl.handle.net/11274/15534
dc.language.isoEnglish
dc.subjectHealth Sciences, Nutrition
dc.subject.otherOsteoarthritis
dc.subject.otherTart cherry
dc.subject.otherMonosodium rat
dc.subject.otherInflammation
dc.subject.otherCartilage
dc.titleChondroprotective action of tart cherry in the monosodium iodoacetate (MIA) rat model of osteoarthritis
dc.typeThesis
dc.type.materialtext
local.embargo.lift2024-08-01
local.embargo.terms2024-08-01
thesis.degree.collegeCollege of Health Sciences
thesis.degree.departmentNutrition and Food Sciences
thesis.degree.disciplineExercise and Sports Nutrition
thesis.degree.grantorTexas Woman's University
thesis.degree.nameMaster of Science
thesis.degree.programAPA 7th edition
thesis.degree.schoolTexas Woman's University

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