Integrative role of the DBL-1/BMP signaling pathway with BLMP-1/BLIMP1 in Caenorhabditis elegans development

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dc.contributor.authorLakdawala, Mohammed Farhan
dc.contributor.authorJoseph, Pamela
dc.contributor.authorGumienny, Tina L.
dc.date.accessioned2021-03-19T17:20:31Z
dc.date.available2021-03-19T17:20:31Z
dc.date.issued2021
dc.descriptionCreative Arts and Research Symposium
dc.descriptionCreative Arts and Research Symposiumen_US
dc.description.abstractAnimals use multiple signaling pathways for cell-to-cell communication for proper development. One signaling pathway is defined by its ligand family of bone morphogenetic proteins (BMP). In the roundworm C. elegans, BMP member DBL-1 has a well-defined, conserved pathway. The DBL-1 signaling pathway is involved in a spectrum of traits, including body size, brood size, and others. How does this BMP pathway control target gene expression? Previous studies in C. elegans show that transcriptional regulator BLMP-1 affects a similar array of traits as DBL-1. However, the relationship between DBL- 1 and BLMP-1 is not studied. We discovered that DBL-1 and DBL-1 signaling are affected by loss of BLMP-1. We also found that DBL-1 negatively regulates blmp-1 expression in a stage-specific manner. Additionally, ChIP-seq, RNA-seq, and co-immunoprecipitation analyses suggest that the DBL-1 pathway and BLMP-1 act together to control expression of some common target genes, further linking these conserved molecular mechanisms during development.
dc.description.departmentBiology
dc.description.sponsorshipSupported by the TWU Research Enhancement Program
dc.identifier.urihttps://hdl.handle.net/11274/12806
dc.language.isoen_USen_US
dc.titleIntegrative role of the DBL-1/BMP signaling pathway with BLMP-1/BLIMP1 in Caenorhabditis elegans developmenten_US
dc.typePosteren_US

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Student Creative Arts and Research Symposium | 2021