Carranza-del Rio, JorgeDursun, NIgarCekmece, CigdemBonikowski, MarcinPyrzanowska, WeronikaDabrowski, EdwardTilton, AnnOleszek, JoyceVolteau, MagaliPage, SimonShierk, AngelaDelgado, Mauricio R.2023-04-062023-04-062022This is the published version of an article that is available at https://doi.org/10.2340/jrm.v54.2540. Recommended citation: Carranza-del Río, J., Dursun, N., Cekmece, C., Bonikowski, M., Pyrzanowska, W., Dabrowski, E., Tilton, A., Oleszek, J., Volteau, M., Page, S., Shierk, A., & Delgado, M. R. (2022). Goal attainment after treatment with Abobotulinumtoxina and a tailored home therapy programme in children with upper limb spasticity: Descriptive, exploratory analysis of a large randomized, controlled study. Journal of Rehabilitation Medicine, 54. This item has been deposited in accordance with publisher copyright and licensing terms and with the author’s permission.https://hdl.handle.net/11274/14802https://doi.org/10.2340/jrm.v54.2540Article originally published in Journal of Rehabilitation Medicine, 54. English. Published online 2022. https://doi.org/10.2340/jrm.v54.2540Objective: This exploratory analysis of a large, randomized, double-blind study (NCT02106351) describes the effect of treatment with abobotulinumtoxinA followed by a tailored home exercises therapy programme in enabling children with upper limb spasticity due to cerebral palsy to achieve their functional goals using goal attainment scaling (GAS).Methods: Children with cerebral palsy and spasticity in ≥ 1 upper limb received up to 4 injection cycles of abobotulinumtoxinA (2 U/kg (cycle 1 only), 8U/kg and 16U/kg) into the elbow and wrist flexors and other upper limb muscles selected to support individual treatment goals. Children followed a home exercises therapy programme, which included stretches and exercises specifically chosen to facilitate goal achievement and engagement in activities.Results: For cycle 1, most children had active function goals set as their primary goal (69.7% vs 19.2% passive function goals). GAS T- scores and goal responder rates at week 16 indicated that most types of primary goal were achieved at least as expected during cycle 1 (all groups). Primary goal GAS T-scores were generally maintained for the first 3 abobotulinumtoxinA treatment cycles.Conclusion: Most children with upper limb spasticity treated with repeat cycles of abobotulinumtoxinA supported by an individualized home exercises therapy programme achieved their functional goals.en-USAbobotulinumtoxin ACerebral palsyGoal attainment scalingPhysical therapiesUpper limb.ArticleCopyright (c) 2022 Jorge Carranza-del Río , Nigar Dursun, Cigdem Cekmece, Marcin Bonikowski, Weronika Pyrzanowska, Edward Dabrowski , Ann Tilton, Joyce Oleszek, Magali Volteau, Simon Page, Angela Shierk, Mauricio DelgadoCC BY-NC 4.0