Duplanty, Anthony A.Levitt, Danielle E.Budnar, Ronald G.Luk, Hui-YingFernandez, AlexanderLayman, Travis J.Fancher, Daniel L.Hill, David W.McFarlin, Brian K.Vingren, Jakob L.2019-03-182019-03-182015This is an abstract of an article that is available at https://doi.org/10.1007/s00421-015-3278-6. Recommended citation: Levitt, D. E., Duplanty, A. A., Budnar, R. G., Luk, H.-Y., Fernandez, A., Layman, T. J., Fancher, D. L., Hill, D. W., McFarlin, B. K., & Vingren, J. L. (2015). The effect of post-resistance exercise alcohol ingestion on lipopolysaccharide-stimulated cytokines. European Journal of Applied Physiology, 116(2), 311–318. https://doi.org/10.1007/s00421-015-3278-6. This item has been deposited in accordance with publisher copyright and licensing terms and with the author’s permission.https://hdl.handle.net/11274/11096https://doi.org/10.1007/s00421-015-3278-6Purpose: To examine the effect of post-resistance exercise alcohol ingestion on lipopolysaccharide (LPS)-stimulated production of IFNγ, TNF-α, IL-1β, IL-6, IL-8, and IL-10. Methods: Recreationally resistance-trained men (n = 10, 25 ± 3 year, 177 ± 7 cm, 83.8 ± 15.7 kg, 14.8 ± 8.5 % body fat) and women (n = 8, 23 ± 2 year, 161 ± 3 cm, 59.5 ± 6.0 kg, 26.5 ± 3.0 % body fat) completed two identical heavy back squat sessions (6 × 10 at 80 % 1 repetition maximum) followed by ingestion of either an alcohol (ALC; 1.09 g ethanol · kg fat-free mass−1) or water (PLA) drink. Blood samples were collected before exercise (PRE), and at 3 h (3 h), and 5 h (5 h) after exercise, stimulated with LPS, and analyzed for IFNγ, TNF-α, IL-1β, IL-6, IL-8, and IL-10 concentrations. Results: There were no drink conditions by time effects for IFNγ, TNF-α, IL-1β, or IL-10. Regardless of condition, resistance exercise induce an increase in IFNγ, TNF-α, and IL-1β at 5 h compared to PRE but a decrease in IL-10 at 3 and 5 h compared to PRE. For ALC, IL-8 was reduced at 5 h compared to PLA. From PRE to 3 h, IL-6 was reduced for ALC but increased for PLA; resistance exercise induced an increase in IL-6 for both conditions at 5 h. Conclusions: Heavy resistance exercise increased production of IFNγ, TNF-α, IL-1β, and Il-6 and decreased production of IL-10. Alcohol ingestion after resistance exercise affected aspects of inflammatory capacity (IL-6 and IL-8 production). It appears that some of the effects previously observed for alcohol ingestion alone on the LPS-stimulated cytokine production were overwhelmed by the response to resistance exercise.en-USResistance exerciseAlcoholLipopolysaccharideInflammationAbstract