The association of depressive symptoms and C-reactive protein and cortisol among women with acute coronary syndrome

dc.contributor.authorMcGlory, Gayle
dc.contributor.committeeChairSymes, Lene
dc.contributor.committeeMemberLangford, Rae
dc.contributor.committeeMemberMcFarlane, Judith M.
dc.date.accessioned2018-12-03T14:38:32Z
dc.date.available2018-12-03T14:38:32Z
dc.date.issued2009-08
dc.description.abstractAcute coronary syndrome (ACS) coupled with depressive symptoms and elevated inflammatory markers can result in poorer health outcomes than ACS alone. To enhance understanding of the relationships between depressive symptoms and inflammatory markers (C-reactive protein and Cortisol) in economically disadvantaged women diagnosed with ACS, a descriptive secondary analysis was completed to examine the association over time (hospitalization, 3-months, and 6-months following hospitalization), between depressive symptoms and select inflammatory markers (e.g., C-reactive protein and Cortisol) in economically disadvantaged women with ACS. This study used Pearson product moment correlation coefficients to examine the relationships between depressive symptoms and inflammatory markers. The Beck's Depression Inventory II (BDI-11) instrument was used to evaluate depressive symptoms. C-reactive protein and Cortisol levels were the inflammatory markers evaluated over time. Troponin 1 levels confirmed that the women had experienced ACS and therefore met the inclusion criteria for the study. The number of participants who experienced depressive symptoms increased from admission (48.8%) to 3-month follow-up (57.5%) and then decreased to the 6-month evaluation (41%). Inflammatory markers (C-reactive protein and Cortisol) showed a decrease in levels from admission to 6-months follow-up which did not support the hypothesis. Although the hypothesis was not supported it is important to continue the search for biomarkers to serve as indicators of the outcomes of post-ACS interventions to treat symptoms of depression and to indicate when additional interventions are needed.en_US
dc.identifier.urihttps://hdl.handle.net/11274/10800
dc.language.isoen_USen_US
dc.subjectHealth and environmental sciencesen_US
dc.subjectPsychologyen_US
dc.subjectAcute coronary syndromeen_US
dc.subjectBiomarkersen_US
dc.subjectC-reactive proteinen_US
dc.subjectCortisolen_US
dc.subjectDepressionen_US
dc.subjectWomenen_US
dc.titleThe association of depressive symptoms and C-reactive protein and cortisol among women with acute coronary syndromeen_US
dc.typeDissertationen_US
thesis.degree.collegeCollege of Nursing
thesis.degree.disciplineNursing Science
thesis.degree.grantorTexas Woman's Universityen_US
thesis.degree.levelDoctoralen_US
thesis.degree.nameDoctor of Philosophyen_US

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