Synthesis of doxorubicin-protein conjugates via cobalt coordination chemistry

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dc.contributor.advisorPetros, Robby
dc.contributor.committeeMemberBeatty, John
dc.contributor.committeeMemberMirsaleh-Kohan, Nasrin
dc.creatorColion, Sara
dc.date.accessioned2023-06-26T16:34:37Z
dc.date.available2023-06-26T16:34:37Z
dc.date.created2023-05
dc.date.issuedMay-23
dc.date.submittedMay-23
dc.date.updated2023-06-26T16:34:38Z
dc.description.abstractThe use of nanotechnology-based drug delivery systems in the context of cancer treatments has the potential to help target drug chemotherapeutics to tumor cells more precisely while simultaneously reducing off-target toxicity. One of the most prescribed chemotherapeutics, doxorubicin, is an anthracyclines drug that is effective in treating cancer; however, the drug exhibits dose-limiting cardiotoxicity. Dox intercalates DNA, resulting in the deterioration of DNA strands and the ultimate inhibition of DNA and RNA synthesis. Doxorubicin’s chemical structure contains a primary amine group that can be used to crosslink it to a protein. This project focuses on using cobalt coordination chemistry as a novel crosslinking strategy to synthesize conjugates of Dox bound human serum albumin (HSA). The synthesis of conjugates of Dox with HSA will be discussed along with methods for characterization via HPLC that allow the number of Dox molecules bound per protein molecule to be determined.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/11274/15118
dc.language.isoEnglish
dc.subjectDoxorubicin solutions
dc.subject.otherCancer
dc.subject.otherDox
dc.subject.otherHSA
dc.subject.otherHPLC
dc.subject.otherDSC
dc.subject.otherMolecules
dc.subject.otherConjugates
dc.subject.otherConcentration
dc.subject.otherBase
dc.subject.otherBulk phase
dc.titleSynthesis of doxorubicin-protein conjugates via cobalt coordination chemistry
dc.typeThesis
dc.type.materialtext
thesis.degree.collegeCollege of Arts and Sciences
thesis.degree.departmentSchool of the Sciences
thesis.degree.disciplineChemistry
thesis.degree.grantorTexas Woman's University
thesis.degree.nameMaster of Science
thesis.degree.programAMA 11th edition

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