Fast-food meal reduces peripheral artery endothelial function but not cerebral vascular hypercapnic reactivity in healthy young men

Date

2018

Authors

Patik, Jordan C.
Tucker, Wesley J.
Curtis, Bryon M.
Nelson, Michael D.
Nasirian, Aida
Park, Suwon
Brothers, Robert M.

Journal Title

Journal ISSN

Volume Title

Publisher

Wiley Open Access

Abstract

Consumption of a representative fast-food meal (FFMeal) acutely impairs peripheral conduit artery vascular function; however, the effect on cerebral vascular function remains unknown. This study tested the hypothesis that a FFMeal would impair cerebral vascular function as indexed by an attenuated increase in cerebral vascular conductance (CVCI) in the middle cerebral artery (MCA) during a hypercapnic challenge. Ten healthy men (age: 24 ± 3 years, BMI: 24.3 ± 3.8 kg/m2) were studied under two conditions; a standardized FFMeal (990 kcals, 50% fat, 36% carbohydrate, 14% protein, and 2120 mg sodium) and a fasting control condition. Basal hemodynamics, cerebral vasomotor reactivity (CVMR), and brachial artery flow-mediated dilation (BA FMD) were completed after an overnight fast (Pre) and again 2 h and 4 h later both days. To assess CVMR, subjects rebreathed from a 5-L bag while MCA velocity (MCAVmean) was measured using transcranial Doppler (TCD) ultrasound and converted into CVCI (MCAVmean/mean arterial pressure). Peripheral artery endothelial function was assessed via BA FMD following a standard 5-min occlusion protocol. As expected, BA FMD was reduced at 2 h (Pre: 6.6 ± 1.7% vs. 5.2 ± 1.8%, P = 0.01). However, despite significant impairment in BA FMD, neither peak CVCI%baseline nor CVMR was affected by the FFMeal (Control–Pre: 1.9 ± 1.1, 2 h: 2.1 ± 1.1, 4 h: 1.7 ± 1.1 ∆CVCI%·∆PETCO2−1 vs. FFMeal–Pre: 2.1 ± 1.1, 2 h: 2.2 ± 0.7, 4 h: 1.9 ± 0.9 ∆CVCI%·∆PETCO2−1, time × condition P = 0.88). These results suggest that cerebral vascular reactivity to hypercapnia in healthy young men is not altered by an acute FFMeal.

Description

Article originally published in Physiological Reports, 6(18). English. Published online 2018. https://doi.org/10.14814/phy2.13867

Keywords

Atherosclerosis, Endothelial function, Human, Postprandial, Western diet

Citation

This is the published version of an article that is available at https://doi.org/10.14814/phy2.13867. Recommended citation: Patik, J. C., Tucker, W. J., Curtis, B. M., Nelson, M. D., Nasirian, A., Park, S., & Brothers, R. M. (2018). Fast-food meal reduces peripheral artery endothelial function but not cerebral vascular hypercapnic reactivity in healthy young men. Physiological Reports, 6(18). This item has been deposited in accordance with publisher copyright and licensing terms and with the author’s permission.