Effect of dexamethasone on blood pressure in the very low birth weight infant
| dc.contributor.author | LeFlore, Judy L. | |
| dc.contributor.committeeChair | Northam, Sally | |
| dc.contributor.committeeMember | Garrison, Deborah | |
| dc.contributor.committeeMember | Engle, William | |
| dc.date.accessioned | 2020-01-15T17:01:30Z | |
| dc.date.available | 2020-01-15T17:01:30Z | |
| dc.date.issued | 2000-12 | |
| dc.description.abstract | Prenatal dexamethasone administration for fetal lung maturation has been reported to affect neonatal blood pressure (BP). Prior to 5/1/94, prenatal dexamethasone was used rarely at the study site, a 997-bed, public, tax-supported hospital. However, after that date dexamethasone was commonly used for pregnancies between 24–34wk gestation. To study the relationship between dexamethasone use and neonatal BP regulation in the first 72 hours after birth, infants with birth weight (BW) less than 1500 grams were examined. Seventy infants born between 5/1/94 and 4/30/95 were exposed to dexamethasone (Group 1) and were compared with 46 matched non-exposed infants born between 5/1/93 and 4/30/94 (Group II). Infants were matched for BW (1166 ± 253 grams vs. 1100 ± 241 grams; mean t SD), gestational age (28.7 ± 2.1 weeks vs. 28.9 ± 1.8 weeks). The groups were comparable for route of delivery, method of measuring BP (direct vs. oscillometric) frequency of RDS, surfactant therapy, need for assisted ventilation, air-leak syndrome, and fluid intake. There were no significant differences between groups for systolic (SBP), diastolic (DBP), or mean (MBP) BP at 1, 6, 12, 24, 48, and 72h after birth. Further, the need for volume expansion and/or pressor support did not differ significantly, 11.4% vs. 6.5%, respectively. When only Group I infants whose mothers received greater than or equal to three doses of prenatal dexamethasone (N = 36) were examined, there still were no differences between groups. BP differences were not observed when infants with BW less than or equal to 750 grams or less than or equal to 1000 grams were analyzed. It was concluded that prenatal dexamethasone did not modify the initial BP, subsequent BP measurements during the first 72 hours after birth, the rate of rise of neonatal BP in the first 72 hours postnatally, or the increase use volume expanders or pressor agents in infants less than or equal to 1500 grams BW. | en_US |
| dc.identifier.uri | https://hdl.handle.net/11274/12107 | |
| dc.language.iso | en_US | en_US |
| dc.subject | Health and environmental sciences | en_US |
| dc.subject | Blood pressure | en_US |
| dc.subject | Dexamethasone | en_US |
| dc.subject | Fetal lung maturation | en_US |
| dc.subject | Infant | en_US |
| dc.subject | Neonatal | en_US |
| dc.subject | Very low birth weight | en_US |
| dc.title | Effect of dexamethasone on blood pressure in the very low birth weight infant | en_US |
| dc.type | Dissertation | en_US |
| thesis.degree.college | College of Nursing | en_US |
| thesis.degree.discipline | Nursing | en_US |
| thesis.degree.grantor | Texas Woman's University | en_US |
| thesis.degree.level | Doctoral | en_US |
| thesis.degree.name | Doctor of Philosophy | en_US |