Does Human Cytomegalovirus Promote Treatment-Resistant Breast Cancer?

dc.contributor.authorGarcia, Erica
dc.contributor.authorSpencer, Juliet
dc.date.accessioned2022-05-03T20:04:02Z
dc.date.available2022-05-03T20:04:02Z
dc.date.issued2022
dc.descriptionTexas Woman's Universityen_US
dc.description.abstractBreast cancer is the most commonly diagnosed cancer in women. There are many known risk factors for breast cancer, but one area merits further research is virus infection. Human Cytomegalovirus (HCMV) infects over half of adults by the age of 40, and recent evidence suggests that HCMV may be linked to cancer progression. A previous study found high levels of HCMV proteins in breast tumor biopsies correlated with low levels of estrogen receptor-α (ERα) and progesterone receptor (PR). To determine if HCMV impacts ER protein levels, we infected two breast cancer cell lines with HCMV. The results show that ERα and PR levels were greatly reduced in the presence of HCMV compared to mock- infected cells. We are investigating the mechanistic basis for this observation, but If HCMV triggers a reduction in hormone receptors in breast cancer cells, then patients may benefit from the addition of antiviral medications to treatment regimens.en_US
dc.description.abstract3rd Place Winner for Science, Technology, Engineering, and Math
dc.identifier.urihttps://hdl.handle.net/11274/13636
dc.language.isoen_USen_US
dc.subjectMolecular Biology
dc.titleDoes Human Cytomegalovirus Promote Treatment-Resistant Breast Cancer?en_US
dc.typePresentationen_US

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