Preemptive perineural bupivacaine attenuates the maintenance of mechanical and cold allodynia in a rat spinal nerve ligation model

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dc.contributor.authorClifford, John L.
dc.contributor.authorMares, Alberto
dc.contributor.authorHansen, Jacob
dc.contributor.authorAveritt, Dayna L.
dc.creator.orcidhttps://orcid.org/0000-0001-8345-4988
dc.date.accessioned2019-10-02T17:27:22Z
dc.date.available2019-10-02T17:27:22Z
dc.date.issued2015
dc.description.abstractBackground: Neuropathic pain is evasive to treat once developed, however evidence suggests that local administration of anesthetics near the time of injury reduces the development of neuropathic pain. As abnormal electrical signaling in the damaged nerve contributes to the initiation and maintenance of neuropathic pain, local administration of anesthetics prior to injury may reduce its development. We hypothesized that local treatment with bupivacaine prior to nerve injury in a rat model of spinal nerve ligation (SNL) would attenuate the initiation and/or maintenance of neuropathic pain behaviors. Methods: On the day prior to SNL, baseline measures of pre-injury mechanical, thermal, and/or cold sensitivity were recorded in adult male Sprague–Dawley rats. Immediately prior to SNL or sham treatment, the right L5 nerve was perineurally bathed in either 0.05 mL bupivacaine (0.5 %) or sterile saline (0.9 %) for 30 min. Mechanical allodynia, thermal hyperalgesia, and/or cold allodynia were then examined at 3, 7, 10, 14 and 21 days following SNL. Results: Rats exhibited both mechanical and cold allodynia, but not thermal hyperalgesia, within 3 days and up to 21 days post-SNL. No significant pain behaviors were observed in sham controls. Preemptive local bupivacaine significantly attenuated both mechanical and cold allodynia as early as 10 days following SNL compared to saline controls and were not significantly different from sham controls. Conclusions: These data indicate that local treatment with bupivacaine prior to surgical manipulations that are known to cause nerve damage may protect against the maintenance of chronic neuropathic pain.en_US
dc.identifier.citationThis is a published version of an article that is available at: https://doi.org/10.1186/s12871-015-0113-x. Recommended citation: Clifford, J. L., Mares, A., Hansen, J., & Averitt, D. L. (2015). Preemptive perineural bupivacaine attenuates the maintenance of mechanical and cold allodynia in a rat spinal nerve ligation model. BMC Anesthesiology, 15(1). This item has been deposited in accordance with publisher copyright and licensing terms and with the author’s permission.en_US
dc.identifier.urihttps://doi.org/10.1186/s12871-015-0113-x
dc.identifier.urihttps://hdl.handle.net/11274/11849
dc.language.isoen_USen_US
dc.publisherBMC Anesthesiologyen_US
dc.rights.licenseCC-BY
dc.subjectNeuropathicen_US
dc.subjectPainen_US
dc.subjectAllodyniaen_US
dc.subjectHyperalgesiaen_US
dc.subjectBupivacaineen_US
dc.subjectPreemptiveen_US
dc.titlePreemptive perineural bupivacaine attenuates the maintenance of mechanical and cold allodynia in a rat spinal nerve ligation modelen_US
dc.typeArticleen_US

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