Cardiac mechanisms for low aerobic power in anthracycline treated, older, long-term breast cancer survivors

dc.contributor.authorBeaudry, Rhys I.
dc.contributor.authorHaykowsky, Mark J.
dc.contributor.authorMacNamara, James P.
dc.contributor.authorTucker, Wesley J.
dc.contributor.authorRao, Roshni
dc.contributor.authorHaley, Barbara
dc.contributor.authorSarma, Satyam
dc.date.accessioned2022-10-18T16:07:52Z
dc.date.available2022-10-18T16:07:52Z
dc.date.issued2022
dc.descriptionArticle originally published in Cardio-Oncology, 8(1). English. Published online 2022. https://doi.org/10.1186/s40959-022-00134-1
dc.description.abstractBreast cancer survivors have reduced peak aerobic capacity (VO2peak) which may be related to latent or lingering chemotherapy induced cardiac damage. Nine, older (67 ± 3 years), long-term survivors (9.8 years) of anthracycline based chemotherapy and age- and sex-matched healthy controls were recruited and tested to determine whether: i) VO2peak remains reduced in long-term survivorship; and ii) reductions in VO2peak are due to cardiac dysfunction. VO2peak was significantly reduced in breast cancer survivors relative to healthy controls (15.9 ± 2.0 vs 19.9 ± 3.1 ml/kg/min, p = 0.006), however the heart rate and stroke volume responses to exercise were normal (heart rate reserve; 88 ± 9 vs 85 ± 10 bpm, p = 0.62: stroke volume reserve; 13 ± 6 vs 13 ± 9 ml,p = 0.94). These findings indicate low-normal ventricular size in long-term breast cancer survivors, but normal reserve function.en_US
dc.identifier.citationThis is the published version of an article that is available at https://doi.org/10.1186/s40959-022-00134-1. Recommended citation: Beaudry, R. I., Haykowsky, M. J., MacNamara, J. P., Tucker, W. J., Rao, R., Haley, B., & Sarma, S. (2022). Cardiac mechanisms for low aerobic power in anthracycline treated, older, long-term breast cancer survivors. Cardio-Oncology, 8(1). This item has been deposited in accordance with publisher copyright and licensing terms and with the author’s permission.en_US
dc.identifier.urihttps://hdl.handle.net/11274/14103
dc.identifier.urihttps://doi.org/10.1186/s40959-022-00134-1
dc.language.isoen_USen_US
dc.publisherBMCen_US
dc.rights.licenseCC BY 4.0
dc.subjectBreast canceren_US
dc.subjectAnthracyclineen_US
dc.subjectCardiac functionen_US
dc.subjectExerciseen_US
dc.subjectAerobic capacityen_US
dc.subjectVO2peaken_US
dc.titleCardiac mechanisms for low aerobic power in anthracycline treated, older, long-term breast cancer survivorsen_US
dc.typeArticleen_US

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