Transcranial direct current stimulation plus concurrent activity may influence task prioritization during walking in people with Parkinson’s disease – initial findings

Date
2018-05
Authors
Swank, Chad
Criminger, Christina
Almutairi, Sattam
Mehta, Jyutika
Journal Title
Journal ISSN
Volume Title
Publisher
Dove Press
Abstract

Introduction: Walking for people with Parkinson’s disease (PD) degrades during motor–cognitive interplay (ie, dual-task conditions). Current management of PD improves motor symptoms but inadequately addresses cognitive function, indicating a necessity for novel interventions. In this pilot study, we examined bi-hemisphere transcranial direct current stimulation (tDCS) with concurrent activity and dual-task walking in people with PD.


Methods: Participants received 3 sessions (tDCSsitting, tDCSbike, tDCSWii) of bilateral tDCS (dorsolateral prefrontal cortex; left = anode, right = cathode) at 2 mA and 1 sham session (tDCSsham). Sessions were randomized, single-blinded, and performed during medication “ON” times separated by 7±2 days. Following each session, participants performed Timed Up and Go (TUG) single, dual-task conditions (TUGalone, TUGmotor, TUGcognitive).


Results: Sixteen participants with PD completed this study (mean age=68.13±9.76 years, ­Unified Parkinson’s Disease Rating Scale mean=40.31±18.27, Repeatable Battery for the Assessment of Neuropsychological Status mean=84.13 [13th percentile]). No differences were observed for TUG conditions between tDCS sessions. Dual task cost for TUGmotor, 14.73% (tDCSSitting), 17.78% (tDCSBike), 15.97% (tDCSWii)), 19.02% (tDCSSham); for TUGcognitive (walking), 20.01% (tDCSSitting), 18.7% (tDCSBike), 31.18% (tDCSWii), 20.01% (tDCSSham); for TUGcognitive (cognitive), 33.72% (tDCSSitting), 14.99% (tDCSBike), 4.42% (tDCSWii), 19.11% (tDCSsham).


Conclusion: Our bi-hemisphere tDCS paired with concurrent activities did not lessen dual-task cost in participants with PD but appeared to influence task prioritization. Further investigation with a larger sample size is warranted.

Description
Article originally published in Journal of Parkinsonism and Restless Legs Syndrome, Volume 8, 25–32. English. Published Online 2018. https://doi.org/10.2147/jprls.s161740
Keywords
Dual task interference, Gait, Executive function, Non-invasive brain stimulation, Novel task, Motor-cognitive interplay
Citation
This is the publisher’s version of an article that is available at https://doi.org/10.2147/jprls.s161740. Recommended citation: Criminger, C., Swank, C., Almutairi, S., & Mehta, J. (2018). Transcranial direct current stimulation plus concurrent activity may influence task prioritization during walking in people with Parkinson's disease–initial findings. Journal of Parkinsonism and Restless Legs Syndrome, Volume 8, 25–32. This item has been deposited in accordance with publisher copyright and licensing terms and with the author’s permission.