Editorial: Cytokine-mediated organ dysfunction and tissue damage induced by viruses

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dc.contributor.authorSpencer, Juliet
dc.contributor.authorReliga, Piotr
dc.contributor.authorLehmann, Michael
dc.creator.orcidhttps://orcid.org/0000-0003-0778-6408
dc.date.accessioned2021-02-10T17:58:23Z
dc.date.available2021-02-10T17:58:23Z
dc.date.issued2020-01-22
dc.description.abstractCytokines are small proteins, mostly secreted into the extracellular environment, that bind to specific cell surface receptors, which mediate cell differentiation, migration, growth, and death. Gene expression and cellular release of cytokines are strictly regulated to assure proper function of cells, tissues, and organs. Upon virus infection, a cell starts producing type I interferons (IFN) and inflammatory cytokines (ICs) to restrict spread and replication of the respective virus. Ideally, the virus is completely eliminated by the immune system and the antiviral mechanisms are turned off within a reasonable time frame. However, there are different scenarios where this process does not work efficiently or does not happen at all, leading to cytokine-mediated organ dysfunction and tissue damage.
dc.identifier.citationThis is the published version of an article that is available at https://doi.org/10.3389/fimmu.2020.00002. Recommended citation: Spencer, J. V., Religa, P., & Lehmann, M. H. (2020). Editorial: Cytokine-mediated organ dysfunction and tissue damage induced by viruses. Frontiers in Immunology, 11. This item has been deposited in accordance with publisher copyright and licensing terms and with the author’s permission.en_US
dc.identifier.urihttps://doi.org/10.3389/fimmu.2020.00002
dc.identifier.urihttps://hdl.handle.net/11274/12672
dc.language.isoen_USen_US
dc.publisherFrontiersen_US
dc.rights.licenseCC-BY
dc.subjectCoxsackievirusen_US
dc.subjectHantavirusen_US
dc.subjectHCMVen_US
dc.subjectHIVen_US
dc.subjectInfluenzaen_US
dc.subjectMHVen_US
dc.subjectRSVen_US
dc.subjectTMEVen_US
dc.titleEditorial: Cytokine-mediated organ dysfunction and tissue damage induced by virusesen_US
dc.typeArticleen_US

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