Editorial: Cytokine-mediated organ dysfunction and tissue damage induced by viruses

Spencer, Juliet
Religa, Piotr
Lehmann, Michael
Journal Title
Journal ISSN
Volume Title

Cytokines are small proteins, mostly secreted into the extracellular environment, that bind to specific cell surface receptors, which mediate cell differentiation, migration, growth, and death. Gene expression and cellular release of cytokines are strictly regulated to assure proper function of cells, tissues, and organs. Upon virus infection, a cell starts producing type I interferons (IFN) and inflammatory cytokines (ICs) to restrict spread and replication of the respective virus. Ideally, the virus is completely eliminated by the immune system and the antiviral mechanisms are turned off within a reasonable time frame. However, there are different scenarios where this process does not work efficiently or does not happen at all, leading to cytokine-mediated organ dysfunction and tissue damage.

Article originally published in Frontiers in Immunology, 11. English. Published online 2020. https://doi.org/10.3389/fimmu.2020.00002
Coxsackievirus, Hantavirus, HCMV, HIV, Influenza, MHV, RSV, TMEV
This is the published version of an article that is available at https://doi.org/10.3389/fimmu.2020.00002. Recommended citation: Spencer, J. V., Religa, P., & Lehmann, M. H. (2020). Editorial: Cytokine-mediated organ dysfunction and tissue damage induced by viruses. Frontiers in Immunology, 11. This item has been deposited in accordance with publisher copyright and licensing terms and with the author’s permission.