Leukocyte subset changes in response to a 164-km road cycle ride in a hot environment

dc.contributor.authorDuplanty, Anthony A.
dc.contributor.authorLuk, Hui Ying
dc.contributor.authorMcKenzie, Amy L.
dc.contributor.authorBudnar, Ronald G.
dc.contributor.authorLevitt, Danielle
dc.contributor.authorFernandez, Alex
dc.contributor.authorLee, Elaine C.
dc.contributor.authorArmstrong, Lawrence E.
dc.contributor.authorVingren, Jakob L.
dc.creator.orcidhttps://orcid.org/0000-0002-3506-048X
dc.date.accessioned2019-03-13T14:26:17Z
dc.date.available2019-03-13T14:26:17Z
dc.date.issued2016
dc.description.abstractThe purpose of this observational study was to determine the circulating leukocyte subset response to completing the 2013 Hotter’N Hell Hundred recreational 164-km road cycle event in a hot and humid environmental condition. Twenty-eight men and four women were included in this study. Whole blood samples were obtained 1-2 hours before (PRE) and immediately after (POST) the event. Electronic sizing/sorting and cytometry were used to determine complete blood counts (CBC) including neutrophil, monocyte, and lymphocyte subsets. The concentration of circulating total leukocytes (103·µL-1) increased 134% from PRE to POST with the greatest increase in neutrophils (319%, p<0.0001). Circulating monocytes (including macrophages) increased 24% (p=0.004) and circulating lymphocytes including B and T cells increased 53% (p<0.0001). No association was observed between rolling time or relative intensity and leukocyte subset. Completing the Hotter n’ Hell Hundred (HHH), a 100 mile recreational cycling race in extreme (hot and humid) environmental conditions, induces a substantial increase in total leukocytes in circulation. The contribution of increases in specific immune cell subsets is not equal, with neutrophils increasing to greater than 4-fold starting values from PRE to POST race. It is likely that exercise in stressful environmental conditions affects the complement of circulating immune cells, although activational state and characterization of specific leukocyte subsets remains unclear. The observed increase in circulating cell sub-populations suggests that the circulating immune surveillance system may be acutely affected by exercise in hot and humid conditions. **This article was originally published by the International Journal of Exercise Science: Luk, Hui Ying; Mckenzie, Amy L.; Duplanty, Anthony A.; Budnar, Ronald G.; Levitt, Danielle; Fernandez, Alex; Lee, Elaine C.; Armstrong, Lawrence E.; and Vingren, Jakob L. (2016) "Leukocyte Subset Changes in Response to a 164-km Road Cycle Ride in a Hot Environment," International Journal of Exercise Science:Vol.9:Iss.1. Available at https://digitalcommons.wku.edu/ijes/vol9/iss1/5.en_US
dc.identifier.citationThis is the published version of an article that is available at https://digitalcommons.wku.edu/ijes/vol9/iss1/5. Recommended citation: Luk, H.Y; Mckenzie, A.L.; Duplanty, A.A.; Budnar, R. G.; Levitt, D.; Fernandez, A.; Lee, E.C.; Armstrong, L.E.; and Vingren, J.L. (2016) Leukocyte subset changes in response to a 164-km road cycle ride in a hot environment. International Journal of Exercise Science, 9(1), 34-46. This item has been deposited in accordance with publisher copyright and licensing terms and with the author’s permission.en_US
dc.identifier.urihttps://hdl.handle.net/11274/11091
dc.identifier.urihttps://digitalcommons.wku.edu/ijes/vol9/iss1/5
dc.language.isoen_USen_US
dc.publisherWestern Kentucky Universityen_US
dc.rightsCC BY-ND 4.0
dc.subjectWhite blood cellsen_US
dc.subjectHeaten_US
dc.subjectUltra-enduranceen_US
dc.subjectNeutrophilsen_US
dc.subjectMonocyteen_US
dc.subjectExerciseen_US
dc.subjectLymphocyteen_US
dc.titleLeukocyte subset changes in response to a 164-km road cycle ride in a hot environmenten_US
dc.typeArticleen_US

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