Browsing Chemistry & Biochemistry - Faculty & Staff by Author "Conrad-Webb, Heather"

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Genetic Mutations in the S-loop of Human Glutathione Synthetase: Links Between Substrate Binding, Active Site Structure and Allostery

Anderson, Mary; Ingle, Brandall; Shrestha, Bisesh; De Jesus, Margarita; Conrad-Webb, Heather; Cundari, Thomas (Elsevier, 2018)

The second step in the biosynthesis of the cellular antioxidant glutathione (GSH) is catalyzed by human glutathione synthetase (hGS), a negatively cooperative homodimer. Patients with mutations in hGS have been reported ...