Biology - Faculty & Staff
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Sex differences in μ-opioid receptor expression in the rat midbrain periaqueductal gray are essential for eliciting sex differences in morphine analgesia
(Journal of Neuroscience, 2008)Opioid-based narcotics are the most widely prescribed therapeutic agent for the alleviation of persistent pain; however, it is becoming increasingly clear that morphine is significantly less potent in women compared with ... -
Preemptive perineural bupivacaine attenuates the maintenance of mechanical and cold allodynia in a rat spinal nerve ligation model
(BMC Anesthesiology, 2015)BACKGROUND Neuropathic pain is evasive to treat once developed, however evidence suggests that local administration of anesthetics near the time of injury reduces the development of neuropathic pain. As abnormal electrical ... -
Euphorbia bicolor (Euphorbiaceae) latex extract reduces inflammatory cytokines and oxidative stress in a rat model of orofacial pain
(Oxidative Medicine and Cellular Longevity, 2019)Recent studies have reported that the transient receptor potential V1 ion channel (TRPV1), a pain generator on sensory neurons, is activated and potentiated by NADPH oxidase-generated reactive oxygen species (ROS). ROS are ... -
Euphorbia bicolor (Euphorbiaceae) latex phytochemicals induce long-lasting non-opioid peripheral analgesia in a rat model of inflammatory pain
(Frontiers MediaFrontiers in Pharmacology, 2019-09-03)The negative side effects of opioid-based narcotics underscore the search for alternative non-opioid bioactive compounds that act on the peripheral nervous system to avoid central nervous system-mediated side effects. The ... -
Mitotic activation of a novel histone deacetylase 3-linker histone H1.3 protein complex by protein kinase CK2
(Journal of Biological Chemistry, 2015-12-09)Histone deacetylase 3 (HDAC3) and linker histone H1 are involved in both chromatin compaction and the regulation of mitotic progression. However, the mechanisms by which HDAC3 and H1 regulate mitosis as well as the factors ... -
Polyphenols extracted from grape powder induce lipogenesis and glucose uptake during differentiation of murine preadipocytes
(Experimental Biology and Medicine, 2016)Assessing the effects of grapes and grape powder extracted polyphenols on lipogenesis and glucose uptake in adipocytes may clarify the risk/benefit of recommending them to individuals with obesity and insulin resistance. ... -
Alleviation of Drought Stress in Arabidopsis thaliana by 17β-Estradiol Application
(American Journal of Plant Sciences, 2016-10)Animal steroidal hormones, including estrogens, are being introduced into the agricultural soil and water supply from increased pharmaceutical and farm waste. Considering the current levels of xenoestrogen contamination ... -
Effects of 17β-Estradiol on Growth, Primary Metabolism, Phenylpropanoid- Flavonoid Pathways and Pathogen Resistance in Arabidopsis thaliana
(Scientific Research Publishing, Inc., 2016-10)Mammalian sex hormones are spread in the environment from natural and anthropogenic sources. In the present study, the effect of estradiol on Arabidopsis thaliana growth primary metabolism, phenylpropanoid and flavonoid ... -
In vitro antioxidant activities and polyphenol contents of seven commercially available fruits
(Wolters Kluger - Medknow, 2016-10)Background: Fruits are considered one of the richest sources of natural antioxidants. Their consumption has been linked to the prevention of oxidative stress‑induced diseases. Objective: In this study, in vitro antioxidant ...
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