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Local resiniferatoxin induces long-lasting analgesia in a rat model of full thickness thermal injury

Salas, Margaux M.; Clifford, John L.; Hayden, Jessica R.; Iadarola, Michael J.; Averitt, Dayna L. (Pain Medicine, 2016-10-28)

Objective Opioid-based analgesics are a major component of the lengthy pain management of burn patients, including military service members, but are problematic due to central nervous system–mediated side effects. Peripheral ...

Euphorbia bicolor (Euphorbiaceae) latex phytochemicals induce long-lasting non-opioid peripheral analgesia in a rat model of inflammatory pain

Basu, Paramita; Tongkhuya, Sirima A.; Harris, Taylor L.; Riley, Angela R.; Maier, Camelia; Granger, John; Wojtaszek, Jennie; Averitt, Dayna L. (Frontiers in Pharmacology, 2019-09-03)

The negative side effects of opioid-based narcotics underscore the search for alternative non-opioid bioactive compounds that act on the peripheral nervous system to avoid central nervous system-mediated side effects. The ...