Now showing items 1-5 of 5
Euphorbia bicolor (Euphorbiaceae) latex extract reduces inflammatory cytokines and oxidative stress in a rat model of orofacial pain
(Oxidative Medicine and Cellular Longevity, 2019)
Recent studies have reported that the transient receptor potential V1 ion channel (TRPV1), a pain generator on sensory neurons, is activated and potentiated by NADPH oxidase-generated reactive oxygen species (ROS). ROS are ...
Preemptive perineural bupivacaine attenuates the maintenance of mechanical and cold allodynia in a rat spinal nerve ligation model
(BMC Anesthesiology, 2015)
Background Neuropathic pain is evasive to treat once developed, however evidence suggests that local administration of anesthetics near the time of injury reduces the development of neuropathic pain. As abnormal electrical ...
Local resiniferatoxin induces long-lasting analgesia in a rat model of full thickness thermal injury
(Pain Medicine, 2016-10-28)
Objective Opioid-based analgesics are a major component of the lengthy pain management of burn patients, including military service members, but are problematic due to central nervous system–mediated side effects. Peripheral ...
Euphorbia bicolor (Euphorbiaceae) latex phytochemicals induce long-lasting non-opioid peripheral analgesia in a rat model of inflammatory pain
(Frontiers in Pharmacology, 2019-09-03)
The negative side effects of opioid-based narcotics underscore the search for alternative non-opioid bioactive compounds that act on the peripheral nervous system to avoid central nervous system-mediated side effects. The ...
Progesterone and allopregnanolone rapidly attenuate estrogen-associated mechanical allodynia in rats with persistent temporomandibular joint inflammation
(Frontiers in Integrative Neuroscience, 2020-05-08)
Temporomandibular joint disorder (TMD) is associated with pain in the joint (temporomandibular joint, TMJ) and muscles involved in mastication. TMD pain dissipates following menopause but returns in some women undergoing ...