Browsing College of Arts & Sciences by Issue Date
Now showing items 1-20 of 62
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The elongin B ubiquitin homology domain
(Journal of Biological Chemistry, 1999)Mammalian Elongin B is a 118-amino acid protein composed of an 84-amino acid amino-terminal ubiquitin-like domain and a 34-amino acid carboxyl-terminal tail. Elongin B is found in cells as a subunit of the heterodimeric ... -
A molecular basis for stabilization of the von hippel-lindau (VHL) tumor suppressor protein by components of the VHL ubiquitin ligase
(Journal of Biological Chemistry, 2002)The multiprotein von Hippel-Lindau (VHL) tumor suppressor (CBCVHL, Cul2-ElonginBC-VHL) and SCF (Skp1-Cul1/Cdc53-F-box protein) complexes are members of structurally related families of E3 ubiquitin ligases that use a ... -
Identification of mammalian mediator subunits with similarities to yeast mediator subunits srb5, srb6, med11, and ROX3
(Journal of Biological Chemistry, 2003)The Mediator is a multiprotein coactivator required for activation of RNA polymerase II transcription by DNA binding transactivators. We recently identified a mammalian homologue of yeast Mediator subunit Med8 and partially ... -
A mammalian homolog of drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator Complex
(Journal of Biological Chemistry, 2003)The multiprotein Mediator complex is a coactivator required for transcriptional activation of RNA polymerase II transcribed genes by DNA binding transcription factors. We previously partially purified a Med8-containing ... -
A mammalian mediator subunit that shares properties with saccharomyces cerevisiae mediator subunit CSE2
(Journal of Biological Chemistry, 2004)The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. We previously identified and partially purified a mammalian Mediator complex ... -
Arginyltransferase, its specificity, putative substrates, bidirectional promoter, and splicing-derived isoforms
(Journal of Biological Chemistry, 2006)Substrates of the N-end rule pathway include proteins with destabilizing N-terminal residues. Three of them, Asp, Glu, and (oxidized) Cys, function through their conjugation to Arg, one of destabilizing N-terminal ... -
Sex differences in μ-opioid receptor expression in the rat midbrain periaqueductal gray are essential for eliciting sex differences in morphine analgesia
(Journal of Neuroscience, 2008)Opioid-based narcotics are the most widely prescribed therapeutic agent for the alleviation of persistent pain; however, it is becoming increasingly clear that morphine is significantly less potent in women compared with ... -
Androgen and estrogen (α) receptor localization on periaqueductal gray neurons projecting to the rostral ventromedial medulla in the male and female rat
(Journal of Chemical Neuroanatomy, 2008-12)The periaqueductal gray (PAG) is involved in many gonadal steroid-sensitive behaviors, including responsiveness to pain. The PAG projects to the rostral ventromedial medulla (RVM), comprising the primary circuit driving ... -
Machiavelli’s politics and critical theory of technology
(Argumentos de Razón Técnica: Revista Española de Ciencia, Tecnología y Sociedad, 2009)This paper has four major parts. First is a discussion of the critical theory of technology offered by Andrew Feenberg in his book, Questioning Technology. I argue that Feenberg’s theory is similar, in important respects, ... -
Ablation of arginylation in the mouse N-end rule pathway: Loss of fat, higher metabolic rate, damaged spermatogenesis, and neurological perturbations
(PLoS ONE, 2009)In the N-end rule pathway of protein degradation, the destabilizing activity of N-terminal Asp, Glu or (oxidized) Cys residues requires their conjugation to Arg, which is recognized directly by pathway’s ubiquitin ligases. ... -
Mouse DFA is a repressor of TATA-box promoters and interacts with the Abt1 activator of basal transcription
(Journal of Biological Chemistry, 2010)Our study of the mouse Ate1 arginyltransferase, a component of the N-end rule pathway, has shown that Ate1 pre-mRNA is produced from a bidirectional promoter that also expresses, in the opposite direction, a previously ... -
How student satisfaction factors affect perceived learning
(Journal of the Scholarship of Teaching and Learning, 2010-01)Data from students in two sections of a general education course offered at a research university in spring 2009 were used to explore whether student satisfaction factors are associated with perceived learning as rated ... -
Contributions of fungi to carbon flow and nutrient cycling from standing dead Typha angustifolia leaf litter in a temperate freshwater marsh
(Association for the Sciences of Limnology and Oceanography, 2011-02-03)Standing dead plant litter often constitutes a large fraction of the detritus in many freshwater marshes and lake littoral habitats. Despite this evidence, microbial decay processes in standing litter and its contribution ... -
Promoting student learning by having college students participate in an online environment
(Journal of the Scholarship of Teaching and Learning, 2011-04)Using data collected in spring 2009 from students at a southern research university enrolled in either of 2 sections of a general education course that fulfilled a social/behavioral sciences graduation requirement, the ... -
Anti-hyperalgesic effects of anti-serotonergic compounds on serotonin- and capsaicin-evoked thermal hyperalgesia in the rat
(Neuroscience, 2012)The peripheral serotonergic system has been implicated in the modulation of an array of pain states, from migraine to fibromyalgia; however, the mechanism by which serotonin (5HT) induces pain is unclear. Peripherally ... -
Sex differences in serotonin enhancement of capsaicin-evoked calcitonin gene-related peptide release from human dental pulp
(Pain, 2012-10)Serotonin (5HT) enhances transient receptor potential V1 channel (TRPV1)–evoked calcitonin gene-related peptide (CGRP) release from female, but not male, human dental pulp. This enhancement occurs greatest during the luteal ... -
Inclusive, Interactive Classroom as Student- Learning Facilitator
(International Journal for the Scholarship of Teaching and Learning, 2013-07)Using principles underlying the social constructivist approach, we redesigned an undergraduate course on social problems, seeking to employ three learning activities (online assignments and small-group and class discussions) ... -
Priming in the microbial landscape: periphytic algal stimulation of litter-associated microbial decomposers
(Ecological Society of America - "Copyright by the Ecological Society of America", 2014-03)Microbial communities associated with submerged detritus in aquatic ecosystems often comprise a diverse mixture of autotrophic and heterotrophic microbes, including algae, bacteria, protozoa, and fungi. Recent studies have ... -
Preemptive perineural bupivacaine attenuates the maintenance of mechanical and cold allodynia in a rat spinal nerve ligation model
(BMC Anesthesiology, 2015)Background Neuropathic pain is evasive to treat once developed, however evidence suggests that local administration of anesthetics near the time of injury reduces the development of neuropathic pain. As abnormal electrical ... -
The 36% Problem
(Springer Link, 2015-11)Student learning assessments—from the institutional level to Academically Adrift—routinely overlook the ways that plagiarism and cheating may contribute to poor outcome performance. The blind spot is a curious one. Faculty ...
