Chemistry & Biochemistry
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Glutathione synthetase: Conserved residues of the substrate loop
(2013-05)The important antioxidant tripeptide glutathione (GSH) is synthesized in two ATP-dependent steps; the second enzyme in the biosynthetic pathway, glutathione synthetase (GS), ligates glycine to γ-glutamylcysteine (γ-GC). ... -
Synthesis, structural and photophysical properties of phosphorescent oligonuclear complexes of monovalent coinage metals with novel compositions
(2013-12)This thesis is a study of monovalent coinage metal complexes made of small molecules and metallopolymers. It has 54pp, 1 table, 38 figures and the references for organometallic and metallopolymers of group 11 elements. It ... -
Damage mechanisms of anticancer agents: Platinum-based drugs and copper complexes
(2018-10-03)Cisplatin and carboplatin, which belong to the platinum based-drugs family are accustomed to treat various types of cancers. Although they have been used widely in chemotherapy, cisplatin and carboplatin are confronting ... -
Novel luminescent metallopolymers of platinum(II), gold(I), copper(I): Their synthesis, characterization and potential optoelectronic applications
(2009-12)This thesis with it 59 pp., 19 Figures and references is a study of group 10 and 11 based metallopolymers. This topic is a part of a research on metallopolymers for various optoelectronic applications. This thesis discusses ... -
Synthesis, characterization, and lighting applications of group 11 metallopolymers with tunable phosphorescence
(2009-12)This thesis with it 66 pp., 3 tables, 26 Figures and references is a study of group 11 monovalent metallopolymers. Three major chapters that involve synthetic strategies to obtain and enhance the phosphorescence of luminescent ... -
Mechanisms of acid catalyzed Z/E isomerization of hydroximates
(2010-08)The acid-catalyzed isomerization of methyl O-methylcinnamohydroximate (1Zb and 1Eb) was investigated with four different acids in acetonitrile at 25 °C. There are two reasonable mechanisms in which isomerization can take ... -
Human glutathione synthetase residues Valine 44 and Valine 45 are required for subunit stability and negative cooperativity
(2011-08)Valine 44 and Valine 45 serve as important residues for human glutathione synthetase (hGS) function and stability given their location at the dimer interface of this enzyme. Computational studies suggest Val45 has more ... -
The element effect in methoxide ion substitution of the (Z) and (E) isomers of O-methyl-4-methoxybenzohydroximoyl halides
(1997-08)The (Z) and (E) isomers ofO-methyl-4-methoxybenzohydroximoyl chloride [p-OCH3ArC( Cl )=NOCH3] and 0-methyl-4-methoxybenzohyd roximoyl bromide [p-OCH3ArC(Br)=NOCH3] were synthesized, and the rates of methoxide substitution ... -
Reaction of (Z)- and (E)-β-chlorocinnamohydroximoyl chlorides with methoxide ion
(2008-12)New α,β-unsaturated hydroximoyl chlorides and hydroximates were synthesized and characterized. 13C NMR, 1H NMR, IR and elemental analysis were determined for each new compound. The kinetics of methoxide ion substitution ... -
Fine and coarse tuning of the photophysical and chemical properties of cuprous iodide complexes with various imine based ligands
(2018-01-09)This thesis is a study of copper iodide complexes with various imine based ligands. It has 150pp, 17 tables, 112 figures and the references for the study of these CuI complexes. The one main project is discussed over four ... -
Volume change associated with the low- to physiological-temperature conformational change in Thermomyces lanuginosus xylanase
(2010-05)Thermomyces lanuginosus is a thermophilic fungus with an optimal thriving temperature of 55°C. We have detected a conformational change in Thermomyces lanuginosus xylanase at 24°C and at pH = 7.0 and 1.0 atm pressure. This ... -
Aspartate 458 and the glycine triad of human glutathione synthetase
(2011-08)Human glutathione synthetase (hGS) catalyzes the second ATP-dependent step in the biosynthesis of glutathione (GSH). Human GS displays negative cooperative to the γ-glutamyl substrate (GAB). The hGS active site has three ... -
Synthesis and characterization of various ruthenium small molecules and metallopolymers for potential use in photovoltaic devices and luminescence properties of N-heterocyclic carbenes and trifluoro methylated tris(pyrazolyl)borate silver (I) acid-base adducts
(2012-08-30)This thesis with its 66 pages, 1 table, 29 figures and 47 references, deals with two major topics involving structure and properties of selected metal complexes and their use in electronic devices. The first chapter discusses ... -
The dimer loop and electrostatic interactions at the dimer interface of human glutathione synthetase
(2012-12)Human glutathione synthetase (hGS) is homodimeric and negatively cooperative toward its γ-glutamyl substrate making it a good model to study protein-protein interactions. The allosteric pathway between hGS active sites is ... -
Understanding the structure and stability of quadruplex nucleic acids formed from human telomeric sequences
(2011-08-30)The human telomere is a sequence of DNA found at the ends of chromosomes consisting of the repeat d(TT AGGG) and serves to protect genetic information against chromosomal degradation. The human telomere is unique in its ... -
Structural and thermodynamic studies of a DNA i-motif: Investigating the monomer, dimer, and tetramer human telomere sequence context
(2015-08-30)elomeres are protein DNA complexes found at the ends of eukaryotic chromosomes. The human telomere sequence has a G-rich strand, (TTAGGG), complemented to a C-rich strand, (CCCTAA). Previous studies of the G-rich strand ... -
Synthesis and characterization of group 11 metal multinuclear pyrazolate complexes with ferrocene and its various derivatives
(2014-08-30)This thesis is a study of coinage metal complexes with various bridging diimine ligands. It has 75pp, 4 tables, 55 figures and the references for the study of group 11 elements. It discusses one main project divided by ...
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