Chemistry & Biochemistry
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Synthesis of doxorubicin-ablumin conjugates via cobalt coordination chemistry: The effect of reaction conditions on overall protein stability
(2020-07-23)Polymer-drug conjugates have become a common tool in therapeutics to reduce the chances of pharmacotoxicity, often seen in patients undergoing chemotherapy, and to enhance targeted drug delivery. The demand for more novel ... -
Characterizing the thermodynamic parameters of anti-cancer drug Carboplatin and DNA through Spectroscopic techniques
(2020-06-03)Spectroscopic techniques have been employed to understand the interactions and thermodynamic parameters between the anti-cancer drug Carboplatin and the DNA oligomer COTAR 2: ATT AAT GGA TCC ATT AAT. This is a self-complementary ... -
Employing chromatographic and spectroscopic methodologies to monitor DNA response to platinum-based chemotherapeutic drugs
(2020-06-16)In order to design platinum-based chemotherapeutic drugs that express low toxicity and high efficiency, their nature of interaction with DNA, effectiveness, as well as their mechanisms need to be better understood. This ... -
Synthesis and characterization of various copper halide complexes with pyrazole and pyridine-based ligands
(2020-02-26)This thesis covers the following research areas: solvent-mediated, solvent-free synthesis and characterization of copper(I)halide complexes and coordination polymers with various pyrazole-based and pyridine-based ligands, ... -
Syntheses and characterizations of mixed-ligand copper(I/II) and silver(I) complexes and metallopolymers with pyrazolate- and phenanthroline-based ligands and poly(4-vinylpyridine)
(2019-12-02)This thesis focuses on the syntheses and characterizations of heteroleptic Cu(I/II) and Ag(I) complexes and coordination polymers with fluorinated-pyrazolate (FPz-) and phenanthrolines (phen) ligands, followed by that of ... -
Human glutathione synthetase reaction order and kinetics examined using spectroscopic and calorimeteric techniques
(2019-03-04)Glutathione (GSH) is a tripeptide important in preventing cellular oxidative damage. Human glutathione synthetase (hGS) catalyzes the second stage of GSH biosynthesis. Homodimeric human glutathione synthetase is negatively ... -
Utilizing solventless and solvent mediated synthesis of novel coordination polymers based on copper bromide / chloride reactions with cyanopyridines
(2019-12-02)This thesis covers the following research areas: solvent-mediated, solvent-free synthesis and characterization of copper(I)halides complexes and coordination polymers with various of cyanopyridine ligands, analyzing the ... -
Copper phenanthroline complexes in a new era: Utilizing “green” chemistry in the synthesis of cu-phen coordination complexes
(2019-01-30)The purpose of this research was to expand on the knowledge of a well know organometallic system: copper phenanthroline complexes. Copper phenanthroline complexes have been widely studied and are currently being investigated ... -
Synthesis of 1-(2-thienyl) thialkane and attempted synthesis of alkyl substituted thiacyclohexanes
(1961-05)It has been known for some time that the sulfur compounds in petroleum products were both obnoxious and detrimental. Therefore, it was essential that they be removed from the crude petroleum during the refining processes. ... -
Investigating the enthalpic properties of Dicationic Alkylammonium Bromide Gemini Surfactants
(2019-06-13)Surfactants reduce the surface tension of water. They appear in many places throughout our lives: in detergents, soaps, gels, creams and cosmetics we apply; in food; and in many prescriptions. Surfactants have substantial ... -
The effects of the Sea World Talented and Gifted Endangered Species Program on the knowledge of seventh graders
(1997-12)This study was conducted to determine if cognitive gains were made by seventh graders after participation in an endangered species program conducted by Sea World. Fifty-seven students attending a private school participated ... -
Glutathione synthetase: Conserved residues of the substrate loop
(2013-05)The important antioxidant tripeptide glutathione (GSH) is synthesized in two ATP-dependent steps; the second enzyme in the biosynthetic pathway, glutathione synthetase (GS), ligates glycine to γ-glutamylcysteine (γ-GC). ... -
Synthesis, structural and photophysical properties of phosphorescent oligonuclear complexes of monovalent coinage metals with novel compositions
(2013-12)This thesis is a study of monovalent coinage metal complexes made of small molecules and metallopolymers. It has 54pp, 1 table, 38 figures and the references for organometallic and metallopolymers of group 11 elements. It ... -
Damage mechanisms of anticancer agents: Platinum-based drugs and copper complexes
(2018-10-03)Cisplatin and carboplatin, which belong to the platinum based-drugs family are accustomed to treat various types of cancers. Although they have been used widely in chemotherapy, cisplatin and carboplatin are confronting ... -
Novel luminescent metallopolymers of platinum(II), gold(I), copper(I): Their synthesis, characterization and potential optoelectronic applications
(2009-12)This thesis with it 59 pp., 19 Figures and references is a study of group 10 and 11 based metallopolymers. This topic is a part of a research on metallopolymers for various optoelectronic applications. This thesis discusses ... -
Synthesis, characterization, and lighting applications of group 11 metallopolymers with tunable phosphorescence
(2009-12)This thesis with it 66 pp., 3 tables, 26 Figures and references is a study of group 11 monovalent metallopolymers. Three major chapters that involve synthetic strategies to obtain and enhance the phosphorescence of luminescent ... -
Mechanisms of acid catalyzed Z/E isomerization of hydroximates
(2010-08)The acid-catalyzed isomerization of methyl O-methylcinnamohydroximate (1Zb and 1Eb) was investigated with four different acids in acetonitrile at 25 °C. There are two reasonable mechanisms in which isomerization can take ... -
Human glutathione synthetase residues Valine 44 and Valine 45 are required for subunit stability and negative cooperativity
(2011-08)Valine 44 and Valine 45 serve as important residues for human glutathione synthetase (hGS) function and stability given their location at the dimer interface of this enzyme. Computational studies suggest Val45 has more ... -
The element effect in methoxide ion substitution of the (Z) and (E) isomers of O-methyl-4-methoxybenzohydroximoyl halides
(1997-08)The (Z) and (E) isomers ofO-methyl-4-methoxybenzohydroximoyl chloride [p-OCH3ArC( Cl )=NOCH3] and 0-methyl-4-methoxybenzohyd roximoyl bromide [p-OCH3ArC(Br)=NOCH3] were synthesized, and the rates of methoxide substitution ... -
Reaction of (Z)- and (E)-β-chlorocinnamohydroximoyl chlorides with methoxide ion
(2008-12)New α,β-unsaturated hydroximoyl chlorides and hydroximates were synthesized and characterized. 13C NMR, 1H NMR, IR and elemental analysis were determined for each new compound. The kinetics of methoxide ion substitution ...
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