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Prenylation-independent activation of RhoA and Rac1: Effects on localization and neurite outgrowth
Rho family guanine nucleotide triphosphatases (GTPases) are molecular switches that play a fundamental role in axon growth and guidance by directing growth cone cytoskeletal changes through interaction with downstream ...
Alteration of prenylation: Effect on neurite outgrowth and Rho GTPase signaling
The action of the 3-hydroxy-3-methyglutaryl coenyzme A (HMG-CoA) reductase inhibitor, lovastatin, promotes neurite outgrowth in some systems and inhibits it in others (Schulz et al., 2004; Holmberg et al., 2006). Anecdotally, ...