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Structural and thermodynamic studies of a DNA i-motif: Investigating the monomer, dimer, and tetramer human telomere sequence context
Telomeres are protein DNA complexes found at the ends of eukaryotic chromosomes. The human telomere sequence has a G-rich strand, (TTAGGG), complemented to a C-rich strand, (CCCTAA). Previous studies of the G-rich strand ...
Glutathione synthetase: Conserved residues of the substrate loop
The important antioxidant tripeptide glutathione (GSH) is synthesized in two ATP-dependent steps; the second enzyme in the biosynthetic pathway, glutathione synthetase (GS), ligates glycine to γ-glutamylcysteine (γ-GC). ...
Synthesis and screening of aplysinopsin analogs as possible serotonin receptor ligands
Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that modulates a number of functions such as mood, sleep, and sexuality. Because the 5-HT2A and 5-HT2C receptor subtypes are closely related, it has ...
Investigations into the unfolding of a DNA quadruplex: Effect of loop sequence
Understanding of the human telomere and telomerase is expected to provide major insights into genome stability, cancer, and telomere-related diseases. Quadruplexes have been received as a potential target for anti-cancer ...