Now showing items 1-10 of 11
Sequencing and characterization of three plasmids from Helicobacter pylori strain AL236
Helicobacter pylori, a microaerophilic, spiral-shaped, Gram negative bacterium is a gastrointestinal pathogen. Plasmids from H. pylori are currently being sequenced and characterized in our laboratory to determine their ...
Effect of Ataxia-Telangiectasia Mutated (ATM) and cell cycle stage on telomere overhang maintenance
Telomeres, the physical ends of chromosomes, are indispensable for maintaining genomic stability. Telomeres end in 3&feet; single stranded G-overhangs. The 3&feet; overhang is a site where telomerase binds and extends short ...
Analysis of the role of SLIK complex in Pol II rRNA synthesis in Saccharomyces cerevisiae
Although rRNA is synthesized by Pol I under normal physiological conditions, stress conditions trigger the synthesis of rRNA by Pol II in Saccharomyces cerevisiae. Mitochondrial dysfunction triggers the polymerase switch; ...
Effect of testosterone on permeability glycoprotein expression in adult rat testes
Permeability glycoprotein (PGP) is a multidrug resistance 1 (MDR1) transporter and its over-expression protects cancer cells from chemotherapy and makes tumors drug-resistant. Therefore, it is important to understand the ...
Investigations into the unfolding of a DNA quadruplex: Effect of loop sequence
Understanding of the human telomere and telomerase is expected to provide major insights into genome stability, cancer, and telomere-related diseases. Quadruplexes have been received as a potential target for anti-cancer ...