Effects of dietary polyunsaturated fatty acids and proteins on serum lipid profiles and renal functions of uremic rats
Wenan, Viera Navara
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Sixty-three male Sprague-Dawley rats were partially nephrectomized and randomly assigned to one of the four experimental diets. All diets were isocaloric and contained the following ingredients: a) 24% Casein - 5% MaxEPA oil (MOCAS), b) 24% Casein- 5% Corn oil (COCAS), c) 24% Soy- 5% MaxEPA oil (MOSOY), and d) 24% Soy- 5% Corn oil (COSOY). Animals were maintained on their corresponding diets for 13 weeks. Blood pressures and serum blood profiles (total protein, albumin, creatinine, triglycerides and total, HDL and LDL cholesterol) were determined. No differences were noted among the groups in serum total protein, albumin, or creatinine, as well as the systolic blood pressure. Rats fed MO diets, regardless of the protein source, had lower serum triglyceride levels. Total and HDL cholesterol concentrations were significantly lower in the MOCAS group when compared to the other three experimental groups. Feeding of the COCAS diet was nonsignificantly associated with high LDL concentrations. MaxEPA oil diets yielded significantly higher concentrations of serum EPA and DHA and significantly lower linoleic and AA concentrations when compared to CO diets. Rats that were maintained on MOSOY diets had the greatest degree of glomerular sclerosis. Urinary total protein concentrations were higher in the COSOY rats when compared to the other groups. Based on the results obtained, previous beneficial effects of MaxEPA oil and soy protein on serum lipid profiles and renal functions were not as apparent .