Faculty & Staff: Recent submissions
Now showing items 1-20 of 1328
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Identification of mammalian mediator subunits with similarities to yeast mediator subunits srb5, srb6, med11, and ROX3
(Journal of Biological Chemistry, 2003)The Mediator is a multiprotein coactivator required for activation of RNA polymerase II transcription by DNA binding transactivators. We recently identified a mammalian homologue of yeast Mediator subunit Med8 and partially ... -
The elongin B ubiquitin homology domain
(Journal of Biological Chemistry, 1999)Mammalian Elongin B is a 118-amino acid protein composed of an 84-amino acid amino-terminal ubiquitin-like domain and a 34-amino acid carboxyl-terminal tail. Elongin B is found in cells as a subunit of the heterodimeric ... -
A molecular basis for stabilization of the von hippel-lindau (VHL) tumor suppressor protein by components of the VHL ubiquitin ligase
(Journal of Biological Chemistry, 2002)The multiprotein von Hippel-Lindau (VHL) tumor suppressor (CBCVHL, Cul2-ElonginBC-VHL) and SCF (Skp1-Cul1/Cdc53-F-box protein) complexes are members of structurally related families of E3 ubiquitin ligases that use a ... -
A mammalian homolog of drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator Complex
(Journal of Biological Chemistry, 2003)The multiprotein Mediator complex is a coactivator required for transcriptional activation of RNA polymerase II transcribed genes by DNA binding transcription factors. We previously partially purified a Med8-containing ... -
A mammalian mediator subunit that shares properties with saccharomyces cerevisiae mediator subunit CSE2
(Journal of Biological Chemistry, 2004)The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. We previously identified and partially purified a mammalian Mediator complex ... -
Arginyltransferase, its specificity, putative substrates, bidirectional promoter, and splicing-derived isoforms
(Journal of Biological Chemistry, 2006)Substrates of the N-end rule pathway include proteins with destabilizing N-terminal residues. Three of them, Asp, Glu, and (oxidized) Cys, function through their conjugation to Arg, one of destabilizing N-terminal ... -
Suffrage in Texas expanded: A history uncovered project
(Texas Library Association, 2022)Suffrage in Texas Expanded (SITE) is a digital humanities project that was initiated by members of the Digital Scholarship Work Group at Texas Woman’s University. Inspired by the 100th anniversary of the ratification of ... -
Ablation of arginylation in the mouse N-end rule pathway: Loss of fat, higher metabolic rate, damaged spermatogenesis, and neurological perturbations
(PLoS ONE, 2009)In the N-end rule pathway of protein degradation, the destabilizing activity of N-terminal Asp, Glu or (oxidized) Cys residues requires their conjugation to Arg, which is recognized directly by pathway’s ubiquitin ligases. ... -
Mouse DFA is a repressor of TATA-box promoters and interacts with the Abt1 activator of basal transcription
(Journal of Biological Chemistry, 2010)Our study of the mouse Ate1 arginyltransferase, a component of the N-end rule pathway, has shown that Ate1 pre-mRNA is produced from a bidirectional promoter that also expresses, in the opposite direction, a previously ... -
Degradation of the separase-cleaved REC8, a meiotic cohesin subunit, by the N-end rule pathway
(Journal of Biological Chemistry, 2016)The Ate1 arginyltransferase (R-transferase) is a component of the N-end rule pathway, which recognizes proteins containing N-terminal degradation signals called N-degrons, polyubiquitylates these proteins, and thereby ... -
Analyzing N-terminal arginylation through the use of peptide arrays and degradation assays
(Journal of Biological Chemistry, 2016)Nα-terminal arginylation (Nt-arginylation) of proteins is mediated by the Ate1 arginyltransferase (R-transferase), a component of the Arg/N-end rule pathway. This proteolytic system recognizes proteins containing N-terminal ... -
The N termini of tar DNA-binding protein 43 (TDP43) C-terminal fragments influence degradation, aggregation propensity, and morphology
(Molecular and Cellular Biology, 2018)Fragments of the TAR DNA-binding protein 43 (TDP43) are major components of intracellular aggregates associated with amyotrophic lateral sclerosis and frontotemporal dementia. A variety of C-terminal fragments (CTFs) ... -
Beta-amyloid induces apoptosis of neuronal cells by inhibition of the Arg/N-end rule pathway proteolytic activit
(Aging, 2019)Alzheimer’s disease (AD) is accompanied by the dysfunction of intracellular protein homeostasis systems, in particular the ubiquitin-proteasome system (UPS). Beta-amyloid peptide (Aβ), which is involved in the processes ... -
BAG6 prevents the aggregation of neurodegeneration-associated fragments of TDP43
(iScience, 2022)Neurodegeneration is associated with the aggregation of proteins bearing solvent-exposed hydrophobicity as a result of their misfolding and/or proteolytic cleavage. An understanding of the cellular protein quality control ... -
Watermelon rind and flesh volatile profiles and cultivar difference
(MDPI, 2022-01-12)Watermelon rind is treated as agricultural waste and commonly discarded, causing environmental issues and biomass loss. This study aimed to identify volatile profiles of watermelon rind and flesh and their cultivar difference. ... -
Free amino acids and volatile aroma compounds in watermelon rind, flesh, and three rind-flesh juice
(MDPI, 2022-04-14)Watermelon rind is treated as agricultural waste, causing biomass loss and environmental issues. This study aimed to identify free amino acids and volatiles in watermelon rind, flesh, and rind-flesh juice blends with ratios ... -
Consumer expectation of flavored water function, sensory quality, and sugar reduction, and the impact of demographic variables and woman consumer segment
(MDPI, 2022-05-16)This study aimed to investigate consumer expectation of flavored water and potential consumer segments. The results showed flavored water was ranked the fourth most popular drink, after plain water, tea, and coffee, by 901 ... -
Consumer hedonic ratings and associated sensory characteristics and emotional responses to fourteen pecan varieties grown in Texas
(2022)Pecan is one of the top five most widely consumed tree nuts, and pecan nut quality is a major factor for consideration in breeding better pecan cultivars for use by producers. However, the pecan industry faces a hurdle to ... -
Aroma and flavor profile of raw and roasted Agaricus bisporus mushrooms using a panel trained with aroma chemicals
(Elsevier, 2020)Agaricus bisporus is the most commonly consumed edible mushroom in the US, but research on its sensory properties is limited. This study characterized aroma and flavor of three raw and roasted A. bisporus mushrooms (white, ... -
Examining the consumer view of refreshing perception, relevant fruits, vegetables, soft drinks, and beers, and consumer age and gender segmentations
(Wiley Online, 2022-03-29)Consumer perspective of refreshing perception is underexplored, despite it being an emotional attribute to describe foods, beverages, hygiene products, and household items. An online survey (N = 1518) was designed to collect ...
