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dc.contributor.authorLanda, Erin Joyen_US
dc.date.accessioned2015-03-24T19:00:12Z
dc.date.available2015-03-24T19:00:12Z
dc.date.copyright2014en_US
dc.date.issued2014-08-22en_US
dc.identifier.urihttp://hdl.handle.net/11274/4880
dc.description.abstractBone is a dynamic tissue with osteoblasts and osteoclasts participating concomitantly in its remodeling process. Blueberries are a rich source of polyphenolic compounds and have been shown to be effective in decreasing incidence/symptoms of chronic inflammatory conditions. The purpose of this study was to assess the effect of blueberry polyphenols as a whole on osteoclasts by assessing markers for activity and differentiation. RAW 264.7 murine macrophage cells were cultured, differentiated into osteoclasts and treated with varying blueberry polyphenols doses. Levels of Tartrate Resistant Acid Phosphatases (TRAP), Nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) were determined. Blueberry polyphenols were shown to be effective by decreasing iNOS, COX-2 and TRAP levels. This study indicates that blueberry polyphenols decrease osteoclast activity through multiple mechanisms such as inflammatory mediators and key bone resorption enzymes which in turn cause a decrease in osteoclast function.en_US
dc.description.sponsorshipJuma, Shanilen_US
dc.description.sponsorshipImrhan, Victorineen_US
dc.description.sponsorshipVijayagopal, Parakaten_US
dc.language.isoen_USen_US
dc.publisherTexas Woman s Universityen_US
dc.subjectNutritionen_US
dc.titleEffect of blueberry polyphenols on osteoclasten_US
dc.typeThesisen_US


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