• Login
    View Item 
    •   The Repository@TWU Home
    • Conferences and Events
    • Student Creative Arts and Research Symposium
    • Student Creative Arts and Research Symposium | 2021
    • View Item
    •   The Repository@TWU Home
    • Conferences and Events
    • Student Creative Arts and Research Symposium
    • Student Creative Arts and Research Symposium | 2021
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    The role of ATE1 in feeding behavior and energy metabolism

    Your browser does not support the video tag.
    View/Open
    Presentation Video (36.49Mb)
    English Subtitles (3.375Kb)
    Date
    2021
    Author
    Alkhatatbeh, Mosleh
    Frayre, Priscila
    Na, Elisa
    Brower, Christopher S.
    Metadata
    Show full item record
    Abstract
    Obesity results from energy imbalance, whereby intake chronically exceeds expenditure. Energy intake is largely regulated by the hypothalamus in response to the hormones leptin and ghrelin. As obesity has been on the rise since the 1960’s, there is an urgent need for a more detailed understanding of energy metabolism at the molecular level. Previously we found that disruption of Ate1 gene function caused loss of fat and resistance to diet-induced obesity in mice. To gain insight into the molecular mechanism of Ate1 function, we compared leptin production and sensitivity between Ate1- containing and Ate1-lacking mice. Here we show that plasma leptin levels are decreased in Ate1-lacking mice but there is no change in leptin responsiveness compared to Ate1- containing mice. This work will elucidate the role of the Ate1 gene in fat and energy metabolism and may provide new therapeutic targets for the pharmacological regulation of obesity.
    URI
    https://hdl.handle.net/11274/12765
    Collections
    • Student Creative Arts and Research Symposium | 2021

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    TDL
    Theme by 
    Atmire NV
     

     

    Browse

    All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    Login

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    TDL
    Theme by 
    Atmire NV