| dc.description.abstract | Human cytomegalovirus (HCMV) manipulates the immune system of its host by encoding viral proteins that imitate host cytokine
and chemokine pathways. The HCMV gene UL111A encodes a homolog of human interleukin-10 (hIL-10), known as cmvIL-10.
cmvIL-10 has many functions, including upregulating signaling from human CXC- chemokine receptor-4 (CXCR4) signaling in
response to its known ligand CXCL12. cmvIL-10 promotes increased intracellular calcium flux and cell migration in response to
CXCL12/CXCR4 that could assist in viral dissemination. Recent studies have shown that extracellular ubiquitin (UB) is also a
natural ligand for CXCR4. This study will focus on whether cmvIL-10 also impacts UB mediated CXCR4 signaling and will examine
the effects of cmvIl-10 on UB induced cell proliferation, migration, and cell signaling pathways. This research will lead to identify
the possible role of cmvIL-10 in manipulating host cell signaling pathways during virus infection. | en_US |
