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dc.contributor.authorTajuddin, Kiran Hina
dc.contributor.authorSpencer, Juliet
dc.date.accessioned2021-01-20T17:45:37Z
dc.date.available2021-01-20T17:45:37Z
dc.date.issued2020
dc.identifier.urihttps://hdl.handle.net/11274/12620
dc.descriptionCreative Arts and Research Symposiumen_US
dc.description.abstractHuman cytomegalovirus (HCMV) manipulates the immune system of its host by encoding viral proteins that imitate host cytokine and chemokine pathways. The HCMV gene UL111A encodes a homolog of human interleukin-10 (hIL-10), known as cmvIL-10. cmvIL-10 has many functions, including upregulating signaling from human CXC- chemokine receptor-4 (CXCR4) signaling in response to its known ligand CXCL12. cmvIL-10 promotes increased intracellular calcium flux and cell migration in response to CXCL12/CXCR4 that could assist in viral dissemination. Recent studies have shown that extracellular ubiquitin (UB) is also a natural ligand for CXCR4. This study will focus on whether cmvIL-10 also impacts UB mediated CXCR4 signaling and will examine the effects of cmvIl-10 on UB induced cell proliferation, migration, and cell signaling pathways. This research will lead to identify the possible role of cmvIL-10 in manipulating host cell signaling pathways during virus infection.en_US
dc.language.isoen_USen_US
dc.titleEffect of cmvIL-10 on Ubiquitin mediated C-X-C receptor 4 signalingen_US
dc.typePosteren_US


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