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Liat1 nucleolar phase separation is regulated by Jmjd6
The Ligand of Ate1 (Liat1) was discovered by its interaction with Ate1, involved in the Ndegron pathway of protein degradation. The characterization and functional significance of Liat1 awaits discovery. While the ...
Removal of Aggregation-Prone Protein Fragments Associated with Neurodegeneration
Intracellular protein aggregates associated with amyotrophic lateral sclerosis and other forms of neurodegeneration include fragments of the TAR DNA binding protein 43 (TDP43). Due to multiple cleavage sites within TDP43, ...
The role of ATE1 in feeding behavior and energy metabolism
Obesity results from energy imbalance, whereby intake chronically exceeds expenditure. Energy intake is largely regulated by the hypothalamus in response to the hormones leptin and ghrelin. As obesity has been on the ...